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. 2016 Dec 12;595(4):1127–1142. doi: 10.1113/JP273299

Figure 3. Recovery of the OFF state of thick filament and duty ratio during unloaded shortening.

Figure 3

A, open circles and left ordinate: S M6 as a function of time following the imposition of unloaded shortening on the tetanus plateau after subtracting the effect on spacing of the instantaneous compliance of the thick filament (from fig. 2 of Linari et al. 2015). Continuous line: exponential fit on open circles assuming as asymptote S M6 at rest (7.17 nm, dashed line). Filled symbols: fraction of the thick filament in the ON state at 10 and 35 ms following the start of unloaded shortening, estimated as [1 – ((S M6,ON – S M6)/(S M6,ON – S M6,OFF))] (right ordinate). B, values of duty ratio (r) after 10 and 35 ms of unloaded shortening under different assumptions as detailed in the text: open circles, all motors are in the OFF state at the end of LR; filled circles and filled triangles, respectively 24 and 56 motors are constitutively ON.