Figure 6.

Substituting the glycine residue G433 by cysteine or serine abolished or reduced the stimulatory effect of t‐DCA on proton‐activated ASIC1a currents, respectively. (A, B, C), Left panels: Representative whole‐cell current traces recorded in oocytes expressing the G433C (A and B) or G433S (C) mutant ASIC1a. Experiments were performed and analyzed as described for the experiments shown in Figure 1A–D. Right panels: Summary of data from similar experiments as shown in the left panel: A (n = 22; N = 3), B (n = 13; N = 3), C (n = 22; N = 3).