Table 4.
Top 20 annotated genes downregulated in EE‐exposed females compared to control females
| Entrez ID | Gene symbol | Gene name | FDR | Log2 fold change |
|---|---|---|---|---|
| 22864 | R3HDM2 | R3H domain‐containing protein 2 isoform X9 | 1.33E‐06 | −12.787 |
| 23017 | FAIM2 | Protein lifeguard 2 isoform 1 | 7.67E‐11 | −12.591 |
| 9671 | WSCD2 | WSC domain‐containing protein 2 | 0.0055 | −11.717 |
| 3149 | HMGB3 | High‐mobility group protein B3 isoform X2 | 6.54E‐14 | −11.604 |
| 5905 | RANGAP1 | Ran GTPase‐activating protein 1 isoform X3 | 0.0067 | −11.488 |
| 54982 | CLN6 | Peromyscus maniculatus bairdii CDP‐diacylglycerol‐inositol 3‐phosphatidyltransferase (Cdipt), transcript variant X2, mRNA | 0.0075 | −11.451 |
| 10390 | CEPT1 | Choline/ethanolaminephosphotransferase 1 isoform 1 | 0.0225 | −11.439 |
| 59338 | PLEKHA1 | Pleckstrin homology domain‐containing family A member 1 isoform X9 | 0.0109 | −11.437 |
| 9915 | ARNT2 | Aryl hydrocarbon receptor nuclear translocator 2 isoform X1 | 2.57E‐14 | −11.130 |
| 3752 | KCND3 | Potassium voltage‐gated channel subfamily D member 3 isoform 1 precursor | 0.0109 | −11.056 |
| 23378 | RRP8 | Ribosomal RNA‐processing protein 8 isoform 2 | 2.05E‐11 | −10.974 |
| 7690 | ZNF131 | Zinc finger protein 131, isoform CRA_a | 5.85E‐05 | −10.866 |
| 113829 | SLC35A4 | UDP‐sugar transporter protein SLC35A4 | 0.0412 | −10.820 |
| 140609 | NEK7 | Microtus ochrogaster NIMA‐related kinase 7 (Nek7), mRNA | 0.0116 | −10.817 |
| 10206 | TRIM13 | E3 ubiquitin‐protein ligase TRIM13 | 0.0126 | −10.684 |
| 745 | MYRF | Myelin regulatory factor isoform X6 | 0.0158 | −10.410 |
| 84915 | FAM222A | Protein FAM222A | 0.0154 | −10.371 |
| 4728 | NDUFS8 | NADH dehydrogenase (ubiquinone) iron‐sulfur protein 8, mitochondrial | 0.0198 | −10.334 |
| 2186 | BPTF | Nucleosome‐remodeling factor subunit BPTF isoform X6 | 0.0348 | −10.330 |
| 1973 | EIF4A1 | Eukaryotic initiation factor 4A‐I (Mesocricetus auratus) | 0.0348 | −10.289 |