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. Author manuscript; available in PMC: 2017 Feb 15.
Published in final edited form as: Hear Res. 2008 May 28;243(1-2):28–34. doi: 10.1016/j.heares.2008.05.008

Fig. 4.

Fig. 4

An example showing 60–100% OHC loss after styrene exposure with an up to 40 dB threshold shift, but without a significant reduction in maximal CAP amplitude at the highest stimulation level of 90 dB SPL. (A): Surface preparation from the middle turn (about 50% from the apex) with less than 20 OHCs remained. The insert shows IHCs in the region with losses of outer pillar cells (marked by asterisks); (B): OHC losses as a function of % distance from the cochlear apex; (C): CAP I/O function at 12 kHz (filled circles), which is related to the center of the injured area. The CAP amplitudes are consistent with the linear I/O line (dashed line), with an about 40-dB threshold shift, but without a significant reduction in the maximal CAP amplitude at the high stimulation level (90 dB SPL). Opened circles are controls; (D): CAP threshold shifts as a function of frequency. The shaded area indicates the injured region in this cochlea. Styrene exposure: 800 mg/kg by gavage, 1/day, 5 days/week, for 3 weeks.