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. 2017 Feb 7;8:14561. doi: 10.1038/ncomms14561

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(a) Contributions of void (ΔV_Void, triangles) and hydration (ΔV_Hyd, upside-down triangles) volume changes to the total volume (ΔV_Tot, circles) changes upon unfolding as a function of protein size. (b) Fractional changes in the total volume ΔV_Tot/V_Tot,N as a function of protein size.