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Pharmacokinetic analysis of afatinib in the PC-9 brain metastasis model. (A) Concentrations of afatinib against time in blood and cerebral spinal fluid (CSF); samples were collected 0.5, 2, 8, and 24 h after the administration of 30 mg/kg afatinib (n=3/time point). (B) Ratio of afatinib exposure in CSF and plasma 0.5, 2, 8, and 24 h after the administration of 30 mg/kg afatinib. Mean±SEM.
