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The simulation results of different dose regimens of ethaselen. (A) The predicted TrxR activity levels in the A549 xenografted nude mice at the dosages of 36, 50, 72, 90, and 108 mg/kg ethaselen. (B) The predicted tumor volumes in the A549 engrafted nude mice at the dosages of 36, 50, 72, 90, and 108 mg/kg ethaselen.
