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Influence of P-gp expression on the chemosensitization effect of SMI. (A–D) MTT assay. MCF-7 human breast cancer cells and derivative P-gp-overexpression MCF-7/ADR cells were treated with ADR or PTX combined with or without SMI (1 and 2 μL/mL) for 48 h. (E, F) Cellular accumulation of ADR or PTX. Breast cancer cells were treated with ADR or PTX with or without SMI for 2 h. Data are presented as the mean±SEM from five independent experiments. *P<0.05, **P<0.01 vs the control group.
