Figure 5. Oral administration of KPT-9274 blocks tumor growth in mice.

10⁶ cells (MDA-MB-231 (A,B,C), SUM159 (D,E,F), or MDA-MB-468 (G,H), all of which are triple negative breast cancer cell lines, were injected into both flanks of female nude mice. (MDA-MB-231: n = 8, treatment group; n = 10, control group; MDA-MB-468: n = 8, treatment group; n = 7, control group; SUM159: n = 5 treatment group; n = 5, control group). Seven days following injection, mice were treated with orally administered KPT-9274 or Placebo (150 mg/kg PO bidx4 for the MDA-MB-231 and SUM159 cells, or 100 mg/kg PO bidx4 for the MDA-MB-468 cells). Tumor volume (V; mm³) was calculated for each cell line (see A,D, and G). Tumor weight was assessed for the MDA-MB-231 cells and the SUM159 cells (see B and E). Body weight of mice (see C,F,H) was monitored throughout the course of dose administration.