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. 2017 Feb 15;7:42492. doi: 10.1038/srep42492

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Left. When a patient-specific bias (PB₂), estimated from the first dialysis session of each patient, is subtracted from the data, a nonlinear relationship can be observed between K_LAB and T_S/A, assessed in the remaining sessions. This observation led to the definition of the final ECG-based [K⁺] estimator (K_ECG = 0.36*T_S/A² + 0.22*T_S/A + PB). This quadratic relationship is very similar to the one describing the dependence of the maximal conductance of I_Kr and I_K1 currents on extracellular [K⁺] at the cellular level (inset panel²⁴). Right: Bland-Altman plot of [K⁺] obtained applying the quadratic estimator and the reference values for [K⁺].