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. 2017 Feb 10;8:14333. doi: 10.1038/ncomms14333

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) The P113 interaction interface on RH5 was mapped to 19 amino acids located within the N terminus of RH5. Fragments of RH5Nt that could be expressed as prey proteins are depicted schematically and were tested for their ability to bind a P113 bait protein by AVEXIS. The K9-K27 fragment represented the minimal binding region. (b) The RH5 interaction interface on P113 was mapped to the N terminus corresponding to a cysteine-rich region encompassed by Y1-K197. Fragments of P113, including the entire ectodomain (EE), that could be expressed as bait proteins are depicted schematically as in a with the approximate locations of the 16 cysteines marked by vertical bars. The proteins were tested for their ability to bind an RH5 prey protein by AVEXIS. Bars represent means±95% confidence intervals n=3; the experiment shown is one of two independent experiments.