Table 1. Demographic and clinical characteristics of patients with major depressive disorder and healthy controls.
| MDD (n = 114) | HC (n = 88) | p value | |
|---|---|---|---|
| Age | 43.51 ± 12.0 | 39.89 ± 14.05 | 0.055 |
| Gender (female) | 90 | 61 | 0.142 |
| Education level | |||
| Elementary and middle school | 27 | 13 | 0.117 |
| High school or college/university | 80 | 64 | |
| Above graduate school | 7 | 11 | |
| HDRS-17 score | 14.81 ± 8.02 | 2.27 ± 2.10 | <0.001 |
| Duration of illness (months) | 45.18 ± 47.47 | ||
| FKBP5 gene rs1360780 | |||
| CC | 72 | 58 | 0.725 |
| CT | 39 | 29 | |
| TT | 3 | 1 | |
| HWE | 0.394 | 0.204 | |
| CC | 72 | 58 | 0.767 |
| CT + TT | 42 | 30 | |
| Drug-naïve/Antidepressant | 53/61 | ||
| CC | 32/40 | 0.697 | |
| CT + TT | 21/21 | ||
| Antidepressant type | |||
| SSRI | 30 | ||
| SNRI | 10 | ||
| NDRI | 6 | ||
| NaSSA | 4 | ||
| Combination | 11 | ||
Data represent mean ± standard deviation for age, HDRS-17 scores, and duration of illness. The p values for distributions of gender, education level, FKBP5 genotype, and drug-naïve patients according to the genotype were obtained by chi-square test. The p values for comparisons of age and HDRS-17 scores were obtained by independent t-test. Allele frequencies (C/T): MDD patients 0.80/0.20, HC subjects 0.82/0.18. MDD, major depressive disorder; HC, healthy controls; HDRS-17, Hamilton Depression Rating Scale; HWE, Hardy-Weinberg equilibrium; SSRI, selective serotonin reuptake inhibitor; SNRI, serotonin and norepinephrine reuptake inhibitor; NDRI, norepinephrine-dopamine reuptake inhibitor; NaSSA, noradrenergic and specific serotonergic antidepressant; Combination, combinations of two or more types of antidepressant.