Table 1. HW/BW coefficient and cardiac function of MI mice treated with siMIAT for 4 weeks.
| Sham (n = 10) | MI (n = 11) | MI + SI (n = 10) | MI + NC (n = 9) | |
|---|---|---|---|---|
| HW, mg | 126.99 ± 1.78 | 188.16 ± 10.12* | 171.81 ± 7.02 | 218.4 ± 7.71 |
| BW, g | 23.05 ± 0.45 | 25.49 ± 0.71 | 25.73 ± 0.42 | 27.13 ± 0.7 |
| HW/BW, mg/g | 5.64 ± 0.08 | 7.45 ± 0.31* | 6.68 ± 0.25 | 8.06 ± 0.24 |
| HR (BPM) | 407.13 ± 15.98 | 433.91 ± 13.31 | 406.22 ± 14.96 | 423.89 ± 12.6 |
| IVSDT, mm | 0.80 ± 0.02 | 0.62 ± 0.08* | 0.92 ± 0.05# | 0.72 ± 0.09 |
| IVSST, mm | 1.24 ± 0.06 | 0.86 ± 0.12* | 1.37 ± 0.07# | 0.99 ± 0.13 |
| LVIDd, mm | 3.33 ± 0.07 | 4.56 ± 0.09* | 4.40 ± 0.18 | 5.07 ± 0.21 |
| LVIDs, mm | 2.11 ± 0.07 | 3.74 ± 0.11* | 3.19 ± 0.14# | 4.24 ± 0.22 |
| EF, % | 67.31 ± 2.4 | 37.05 ± 2.46* | 53.15 ± 2.37# | 33.75 ± 3.83 |
| FS, % | 36.74 ± 1.87 | 17.91 ± 1.33* | 27.36 ± 1.48# | 16.43 ± 2.09 |
MI indicates myocardial infarction; SI, lentivirus carrying siRNA-MIAT; NC, empty lentivirus; HW, heart weight; BW, body weight; HW/BW, ratio of HW to BW; HR, heart rate; LVIDd, left ventricular diastolic diameter; LVIDs, left ventricular systolic diameter; IVSDT, interventricular septum diastolic thickness; IVSST, interventricular septum systolic thickness; FS, fractional shortening; and EF, ejection fraction. Data are expressed as mean ± SEM, *P < 0.05 vs sham; #P < 0.05 vs MI.