Table 2. Cardiovascular risk factors in patients with pulmonary arterial hypertension and age and sex-matched general population.
| PAH (n = 140) |
Controls (n = 2413) |
p-value |
||||
|---|---|---|---|---|---|---|
| f (n = 94) | m (n = 46) | f (n = 1245) | m (n = 1168) | f | m | |
| Age (years) | 43.6 ± 17.2 | 41.6 ± 16.4 | 44.8 ± 27.1 | 42.9 ± 24.0 | 0.49 | 0.56 |
| BMI (kg/m2) | 23.8 ± 4.16 | 24.9 ± 5.2 | 25.9 ± 7.3 | 27.1 ± 6.7 | <0.001 | 0.002 |
| SBP (mmHg) | 109.2 ± 16.9 | 108.9 ± 16.6 | 130.1 ± 30.0 | 136.7 ± 26.9 | <0.0001 | <0.0001 |
| DBP (mmHg) | 70.3 ± 10.4 | 70.0 ± 11.3 | 80.6 ± 13.1 | 82.4 ± 15.7 | <0.0001 | < 0.0001 |
| LDL-C (mmol/l) | 2.6 ± 0.8 | 2.3 ± 0.9 | 3.2 ± 1.1 | 3.2 ± 1.2 | <0.0001 | < 0.0001 |
| LDL-C (mmol/l)[without statins]* | 2.6 ± 0.8 | 2.3 ± 0.8 | 3.3 ± 1.1 | 3.3 ± 1.2 | <0.0001 | < 0.0001 |
| HDL-C (mmol/l) | 1.3 ± 0.4 | 1.1 ± 0.3 | 1.4 ± 0.4 | 1.2 ± 0.5 | 0.02 | 0.18 |
| TG (mmol/l) | 1.3 ± 0.7 | 1.3 ± 0.8 | 1.1 ± 0.8 | 1.6 ± 1.6 | 0.054 | 0.19 |
| Glucose (mmol/l) | 5.4 ± 1.7 | 5.5 ± 0.9 | 5.0 ± 1.0 | 5.3 ± 1.6 | 0.0003 | 0.49 |
| Diabetes | 10% | 3% | 5.9% | 4.6% | 0.17 | 0.88 |
| Statin use | 19% | 21% | 11.9% | 11.2% | 0.06 | 0.07 |
| Hypertension | 21% | 32% | 25% | 28.2% | 0.46 | 0.69 |
| Active smoker | 4.9% | 7.2% | 27.1% | 35.6% | <0.0001 | 0.0001 |
BMI – body mass index, DBP – diastolic blood pressure, f – female, m – male, HDL – high-density lipoprotein, LDL – low-density lipoprotein, PAH – pulmonary arterial hypertension, SBP – systolic blood pressure, TG – triglycerides *the number of patients who had not used statins are as follows: in PAH group: 76 females and 36 males; in control group 1097 females and 1037 males.