Table 1. Effect of TGFβ on p190-B^−/− HSPC engraftment.

	Chimera>1%	Chimera<1%	Total mice transplanted	P value
p190-B−/−	9	7	16
p190-B−/−+rTGFβ1	4	9	13	0.0006*
p190-B−/−+rTGFβ1+p38 inhi	13	7	20	< 0.0001†

1T p190-B^−/− LSK-SLAM cells (300) were treated ex vivo with rTGF-β1 alone or rTGF-β1+SB203580 for 48 h, and transplanted in competition with 200,000 CD45.1⁺ cells. Table shows numbers of mice exhibiting more than 1% contribution to both myeloid and lymphoid lineages in PB (positive mice) and numbers of mice with less than 1% contribution in at least one lineage (negative mice) (2–3 independent experiments). P values were calculated by Fisher exact 2 × 2 contingency table by comparing per cent of negative and positive mice of the following groups: *p190-B^−/− vs p190-B^−/−+rTGF-β1, and †p190-B^−/−+rTGF-β1 vs p190-B^−/−+rTGF-β1+ SB203580. Difference between the three groups was analysed by χ² test, P<0.0001.