Table 2. Metabolites that varied among CHB, HBV-associated cirrhosis and HBV-associated HCC groups.
| Metabolites | CHB | HBV-associated cirrhosis | HBV-associated HCC |
|---|---|---|---|
| lysoPC a C18:0 (μmol/L) | 34.09(24.77–43.48) | 23.68(18.31–35.05)*** | 22.82(15.34–30.84)***# |
| lysoPC a C18:2 (μmol/L)Δ | 23.66(18.48–29.08) | 19.73(13.19–25.76)** | 15.21(10.54–20.96)***## |
| lysoPC a C20:3 (μmol/L)Δ | 1.51(1.18–1.94) | 1.19(0.84–1.57)*** | 0.97(0.77–1.50)***# |
| lysoPC a C20:4 (μmol/L)Δ | 4.61(3.51–6.18) | 3.52(2.56–4.91)*** | 3.07(2.36–4.34)***# |
| lysoPC a C24:0 (μmol/L) | 0.42(0.26–0.55) | 0.30(0.19–0.45)** | 0.28(0.16–0.42)***# |
| PC ae C42:1 (μmol/L) | 0.34(0.28–0.40) | 0.29(0.21–0.37)*** | 0.26(0.20–0.32)***# |
| AC C18:2(μmol/L)Δ | 0.09(0.05–0.13) | 0.14(0.08–0.19)*** | 0.11(0.07–0.16)**# |
| AC C3-OH (μmol/L) | 0.18(0.14–0.22) | 0.14(0.12–0.19)** | 0.17(0.12–0.22)# |
| SM C24:1 (μmol/L) | 28.45(18.79–39.37) | 21.58(13.02–33.09)** | 28.02(16.94–48.20)## |
Values are expressed as medians (25th, 75th centiles). P values were calculated from non-parametric Kruskal-Wallis test for continuous variables and adjusted by FDR method. *p < 0.05; **p < 0.01; ***p < 0.001 when compared to CHB. #p < 0.05; ##p < 0.01; ###p < 0.001 when compared to HBV-associated cirrhosis. ΔThe metabolites are still independent variables for disease classification considering the effect of age, gender and BMI based on multiple logistic regression. Abbreviations: lysoPC a C18:0, lysophosphatidylcholine acyl C18:0; lysoPC a C18:2, lysophosphatidylcholine acyl C18:2; lysoPC a C20:3, lysophosphatidylcholine acyl C20:3; lysoPC a C20:4, lysophosphatidylcholine acyl C20:4; lysoPC a C24:0, lysophosphatidylcholine acyl C24:0; PC ae C42:1, phosphatidylcholine acyl-alkyl C42:1; AC C18:2, octadecadienylcarnitine; AC C3-OH, hydroxypropionylcarnitine; SM C24:1, sphingomyelin C24:1.