Table 5. 9 metabolites varied in different HBV-DNA in HBV-related diseases.
| Variables | HBV-DNA Negative |
HBV-DNA Positive |
||||
|---|---|---|---|---|---|---|
| CHB | HBV-associated cirrhosis | HBV-associated HCC | CHB | HBV-associated cirrhosis | HBV-associated HCC | |
| N | 48 | 72 | 69 | 88 | 32 | 26 |
| Age(ys) | 45.50(34.00–56.00) | 55.00(48.00–63.25)*** | 55.00(47.00–61.00)*** | 40.00(30.75–49.00) | 58.00(52.75–60.50)*** | 57.50(48.75–62.00)*** |
| BMI(kg/m2) | 23.74(22.96–25.18) | 23.44(21.41–25.1) | 22.60(20.07–24.22)* | 23.57(20.96–24.60) | 23.34(20.27–25.44) | 20.52(18.20–23.36)**# |
| Gender(F/M) | 16/32 | 32/40 | 10/59*### | 35/53 | 11/21 | 4/22 |
| lysoPC a C18:0(μmol/L) | 35.42(27.53–43.95) | 24.90(18.31–34.83)*** | 22.34(14.99–30.82)*** | 33.87(24.36–42.51) | 23.27(18.35–35.88)* | 25.25(17.54–32.28)** |
| lysoPC a C18:2(μmol/L)Δ | 25.84(20.64–36.35) | 20.14(13.54–26.11)*** | 15.71(10.48–20.72)***## | 22.86(17.17–27.23) | 17.41(12.71–25.44)* | 14.61(10.60–21.41)** |
| lysoPC a C20:3(μmol/L)Δ | 1.69(1.22–2.12) | 1.17(0.88–1.52)*** | 0.98(0.77–1.48)*** | 1.46(1.16–1.81) | 1.34(0.76–1.72) | 0.96(0.77–1.49)** |
| lysoPC a C20:4(μmol/L)Δ | 5.17(3.89–6.75) | 3.46(2.56–4.70)*** | 3.06(2.31–4.27)*** | 4.42(3.25–5.99) | 3.75(2.63–5.01) | 3.21(2.57–4.73)** |
| lysoPC a C24:0(μmol/L) | 0.41(0.26–0.55) | 0.31(0.20–0.42)* | 0.29(0.17–0.40)** | 0.44(0.26–0.55) | 0.24(0.18–0.54) | 0.24(0.16–0.44)* |
| PC ae C42:1(μmol/L) | 0.34(0.29–0.40) | 0.29(0.22–0.35)** | 0.26(0.20–0.32)*** | 0.33(0.28–0.40) | 0.30(0.20–0.37) | 0.26(0.21–0.31)*** |
| AC C18:2(μmol/L)Δ | 0.08(0.04–0.12) | 0.15(0.10–0.21)*** | 0.11(0.07–0.16)*## | 0.10(0.06–0.13) | 0.11(0.06–0.15) | 0.11(0.06–0.16) |
| AC C3-OH(μmol/L) | 0.19(0.16–0.24) | 0.14(0.12–0.18)*** | 0.16(0.12–0.21)** | 0.16(0.13–0.20) | 0.15(0.10–0.20) | 0.18(0.12–0.23) |
| SM C24:1(μmol/L) | 29.81(23.18–38.10) | 22.97(15.31–34.02) | 27.59(16.48–47.61) | 28.02(17.96–40.26) | 18.54(10.29–30.55)* | 29.33(18.88–49.27)# |
Values are expressed as medians (25th, 75th centiles) or frequencies. P values were calculated from non-parametric Kruskal-Wallis test for continuous variables, Fisher’s exact test for categorical variables for multiple comparisons correction and adjusted by the FDR method. *p < 0.05; **p < 0.01; ***p < 0.001 when compared to CHB. #p < 0.05; ##p < 0.01; ###p < 0.001 when compared to HBV-associated cirrhosis. ΔThe metabolites are still independent variables for disease classification considering the effect of age, gender and BMI based on multiple logistic regression. HBV-DNA Class, Negative: HBV-DNA < 1E + 03, Positive: HBV-DNA >= 1E + 03.