Table 1. Characterization of the subjects.
| Patient | Age yr | BMI kg/m2 | Diagnosis | Diagnostic test | GH peak μg/l | GH dose mg daily | HbA1c |
Insufficient pituitary axes | |
|---|---|---|---|---|---|---|---|---|---|
| mmol/mol | % | ||||||||
| 1 | 68 | 32.8 | Pituitary apoplexy | Insulin tolerance test | 0.08 | 0.15 | 34 | 5.3 | GH, T, C, Gn |
| 2 | 67 | 26.4 | Pituitary apoplexy | Insulin tolerance test | 0.99 | 0.4 | 41 | 5.9 | GH, T, C, Gn |
| 3 | 26 | 26.0 | Congenital hypopituitaism | GHRH plus arginine stimulation test | 1.61 | 0.3 | 36 | 5.4 | GH, T, C |
| 4 | 48 | 31.7 | Pituitary apoplexy | Insulin tolerance test | 0 | 0.5 | 39 | 5.7 | GH, T, C, Gn |
| 5 | 67 | 27.0 | Pituitary adenoma, surgical treatment and radiotherapy | Insulin tolerance test | 0.41 | 0.2 | 41 | 5.9 | GH, T, C, Gn |
| 6 | 52 | 30.4 | Clinically nonfunctioning pituitary adenoma | Arginine stimulation test | 1.12 | 0.3 | 40 | 5.8 | GH, T, C, Gn |
| 7 | 50 | 25.8 | Pituitary cyst, surgical treatment | Insulin tolerance test | 0.20 | 0.3 | 33 | 5.2 | GH, T, C, Gn |
| 8 | 42 | 42.0 | Traumatic brain injury | Arginine stimulation test | 0.13 | 0.3 | 30 | 4.9 | GH, T, C, Gn |
BMI, body mass index; IGF-I levels at baseline during GH substition. GH, growth hormone; T, thyrotropin; C, corticotropin; Gn, gonadotropin.