TABLE 2.
Estimation of rate of evolution of Vietnamese H5 viruses, 2012 to 2015
| Stratification | Uncorrelated relaxed clock model | Mean substitution rate (×10−3) | 95% HPDa interval (×10−3) |
|---|---|---|---|
| Clade | |||
| 1.1.2 | Lognormal | 5.69 | 4.72 to 6.69 |
| 2.3.2.1c | Lognormal | 6.87 | 5.39 to 8.40 |
| 2.3.4.4 | Lognormal | 5.98 | 4.90 to 7.16 |
| Gene | |||
| PB2 | Exponentialb | 4.55 | 3.54 to 5.78 |
| PB1 | Lognormal | 4.18 | 3.61 to 4.76 |
| PA | Lognormal | 3.83 | 3.27 to 4.37 |
| HA | Lognormal | 5.61 | 4.98 to 6.25 |
| NP | Lognormal | 3.39 | 2.70 to 4.12 |
| NA | Lognormal | 4.83 | 4.25 to 5.42 |
| MP | Lognormal | 2.63 | 2.10 to 3.13 |
| NS | Lognormal | 4.80 | 3.085 to 6.66 |
a
HPD, highest posterior density.
b
An exponential model was used due to the small effective sample size with the lognormal model.