TABLE 1.

Summary of cellular genes differentially expressed in TG of latently infected calves and uninfected calves

Gene name	Relative gene expression during latency	Gene description
HMGA1	+2.8	High-mobility group AT–hook 1
MAN2B1	+2.2	Mannosidase, alpha, class 2B, member 1
DSG2	+2.1	Desmoglein-2
SLC12A3	+2	Solute carrier family 12 (sodium/chloride transporters), member 3
IGF2BP3	+2	Insulin-like growth factor 2 mRNA binding protein 3
Cytochrome b-561	+1.9	An ascorbate-dependent oxidoreductase family member involved with electron transport
C1QB	−6.7	Complement component 1, q subcomponent, B chain
BRB	−4.8	Brain RNase
LOC788911	−4.2	Similar to autotaxin isoform preproprotein
GMFG	−3.6	Glia maturation factor, gamma
APOA1	−3.6	Apolipoprotein A-I
FZD8	−2.4	Frizzled homolog 8 (Drosophila)

^aThe top 6 genes that were induced and the top 6 genes that were repressed in TG during latency are listed. The changes in the levels of expression along with a brief description of the gene are included. To determine the genes differentially expressed over time, we compared the values for latently infected TG from 3 calves to those for uninfected TG from 3 calves using a random-variance F test and then selected genes with a false discovery rate of <10%. Fold changes in expression for each gene differentially expressed in latently infected calves relative to the value for the group of uninfected calves were calculated.