Table 4.
Association between WMH burden and age acceleration estimates
| Horvath predictor | Hannum et al. predictor | |||||
|---|---|---|---|---|---|---|
| Beta (SD)a | P value | % variance explained | Beta (SD)a | P value | % variance explained | |
| Model 1 | 0.007 (0.003) | 0.0287 | 0.61 | 0.011 (0.003) | 0.0005 | 1.51 |
| Model 2 | 0.007 (0.003) | 0.0134 | 0.74 | 0.009 (0.003) | 0.0044 | 1.12 |
| Model 3 | 0.007 (0.003) | 0.0258 | 0.60 | 0.009 (0.003) | 0.0162 | 0.69 |
Model 1: adjusted for age at brain MRI and sex. Model 2: adjusted for age at brain MRI, sex, body mass index, systolic blood pressure, hypertension, diabetes, and current smoking. Model 3: adjusted for covariates in model 2 and white blood cell composition
SD standard deviation
aWMH grade unit