Table 1.

Clustered functional annotations for genes differentially expressed between baseline and following EGF stimulation. Significant DAVID functional annotations following our clustering mechanism for A. genes differentially expressed in StHdh^Q7/7 and StHdh^Q111/111 cells between baseline and following EGF stimulation, and B. genes with a significant EGF x Genotype interaction.

A
Node	StHdhQ7/7		StHdhQ111/111
	p-value	No. genes	p-value	No. genes
PIRSF001719:FOS TRANSFORMING PROTEIN			9.52 × 10− 4	3
GO:0051789 ~ RESPONSE TO PROTEIN STIMULUS			1.52 × 10− 3	6
GO:0048589 ~ DEVELOPMENTAL GROWTH			2.81 × 10− 3	6
GO:0003002 ~ REGIONALIZATION			2.28 × 10− 4	10
DEVELOPMENTAL PROTEIN			3.47 × 10− 3	16
GO:0006355 ~ REGULATION OF TRANSCRIPTION, DNA-DEPENDENT	8.13 × 10− 12	45	9.16 × 10− 13	45
GO:0048514 ~ BLOOD VESSEL MORPHOGENESIS	1.35 × 10− 6	13
IPR013087:ZINC FINGER, C2H2-TYPE/INTEGRASE, DNA-BINDING	6.31 × 10− 5	15
GO:0045859 ~ REGULATION OF PROTEIN KINASE ACTIVITY	1.50 × 10− 4	10
GO:0048729 ~ TISSUE MORPHOGENESIS	2.13 × 10− 4	11
GO:0051094 ~ POSITIVE REGULATION OF DEVELOPMENTAL PROCESS	4.65 × 10− 4	10	2.28 × 10− 4	10
MMU04010:MAPK SIGNALLING PATHWAY	4.88 × 10− 4	11	5.26 × 10− 5	11
GO:0044092 ~ NEGATIVE REGULATION OF MOLECULAR FUNCTION	2.86 × 10− 3	7
GO:0009611 ~ RESPONSE TO WOUNDING	3.14 × 10− 3	11
GO:0048511 ~ RHYTHMIC PROCESS	3.71 × 10− 3	6	3.47 × 10− 4	7

B
Node	p-value	No. genes
PHOSPHOPROTEIN	8.01 × 10− 14	228
GO:0042127 ~ REGULATION OF CELL PROLIFERATION	1.08 × 10− 11	44
TRANSCRIPTION REGULATION	5.48 × 10− 10	75
GO:0048598 ~ EMBRYONIC MORPHOGENESIS	2.43 × 10− 8	30
GO:0040007 ~ GROWTH	1.55 × 10− 6	19
GO:0007507 ~ HEART DEVELOPMENT	3.10 × 10− 6	20
MMU04010:MAPK SIGNALLING PATHWAY	3.42 × 10− 6	22
MMU04350:TGF-BETA SIGNALLING PATHWAY	1.21 × 10− 5	12
GO:0045596 ~ NEGATIVE REGULATION OF CELL DIFFERENTIATION	1.26 × 10− 5	17
GO:0051789 ~ RESPONSE TO PROTEIN STIMULUS	5.81 × 10− 5	11
GO:0010941 ~ REGULATION OF CELL DEATH	7.28 × 10− 5	31
GO:0051094 ~ POSITIVE REGULATION OF DEVELOPMENTAL PROCESS	9.11 × 10− 5	17
GO:0048608 ~ REPRODUCTIVE STRUCTURE DEVELOPMENT	9.60 × 10− 5	13
GO:0008201 ~ HEPARIN BINDING	1.75 × 10− 4	10
GO:0022405 ~ HAIR CYCLE PROCESS	2.20 × 10− 4	8
GO:0043583 ~ EAR DEVELOPMENT	2.61 × 10− 4	11
METAL-BINDING	3.03 × 10− 4	96
MMU05210:COLORECTAL CANCER	3.35 × 10− 4	10
GO:0007242 ~ INTRACELLULAR SIGNALLING CASCADE	3.49 × 10− 4	41
GROWTH FACTOR	6.52 × 10− 4	11
GO:0007178 ~ TRANSMEMBRANE RECEPTOR PROTEIN SERINE/THREONINE KINASE SIGNALLING PATHWAY	6.96 × 10− 4	10
GO:0006928 ~ CELL MOTION	8.90 × 10− 4	21
DEVELOPMENTAL PROTEIN	9.92 × 10− 4	34
GO:0009968 ~ NEGATIVE REGULATION OF SIGNAL TRANSDUCTION	1.18 × 10− 3	13
GO:0048145 ~ REGULATION OF FIBROBLAST PROLIFERATION	1.33 × 10− 3	5
GO:0001890 ~ PLACENTA DEVELOPMENT	1.43 × 10− 3	9
MMU05222:SMALL CELL LUNG CANCER	1.46 × 10− 3	9
GO:0048008 ~ PLATELET-DERIVED GROWTH FACTOR RECEPTOR SIGNALLING PATHWAY	2.29 × 10− 3	5
GO:0030155 ~ REGULATION OF CELL ADHESION	2.35 × 10− 3	9
ALTERNATIVE SPLICING	2.63 × 10− 3	130
GO:0017017 ~ MAP KINASE TYROSINE/SERINE/THREONINE PHOSPHATASE ACTIVITY	2.64 × 10− 3	4
CLEAVAGE ON PAIR OF BASIC RESIDUES	3.25 × 10− 3	14
GO:0045165 ~ CELL FATE COMMITMENT	3.72 × 10− 3	11
GO:0008285 ~ NEGATIVE REGULATION OF CELL PROLIFERATION	4.05 × 10− 3	14
GO:0032869 ~ CELLULAR RESPONSE TO INSULIN STIMULUS	4.10 × 10− 3	6
GO:0001570 ~ VASCULOGENESIS	4.10 × 10− 3	6
CYCLIN	4.55 × 10− 3	6
GO:0021915 ~ NEURAL TUBE DEVELOPMENT	4.56 × 10− 3	8
APOPTOSIS	4.66 × 10− 3	17
GO:0051056 ~ REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION	4.71 × 10− 3	14
GO:0045765 ~ REGULATION OF ANGIOGENESIS	5.00 × 10− 3	6