. Author manuscript; available in PMC: 2017 Sep 2.

Published in final edited form as: J Proteome Res. 2016 Aug 5;15(9):3388–3404. doi: 10.1021/acs.jproteome.6b00601

Table 1.

Relative Abundances (NSAF), Fractional Turnover Rate (k), and Relative Production Rates (RPR) of Plasma Proteins

			NSAF ratio	fractional turnover rate (%/h)		RPR ratio
accession	name of protein	molecular function	WD/ SD	SD	WD	WD/ SD
Complement/Immune Response
218156289	complement factor B isoform 1 precursor	serine-type endopeptidase	1.59	10.79 ± 1.07	11.29 ± 1.89	1.66^c
568966398	complement factor D isoform X1	serine-type endopeptidase	0.54	3.72 ± 0.03	3.22 ± 0.03^b	0.46^c
109627652	complement factor H precursor	C3b binding	0.81	4.43 ± 0.22	5.57 ± 0.28^b	1.02
568921715	complement factor I isoform X3	complement activation	0.88	5.21 ± 1.04	6.22 ± 0.72	1.05
114326449	properdin precursor (factor P)	complement activation	1.26	2.11 ± 0.26	0.71 ± 0.07^b	0.43^c
126518317	complement C3 precursor	endopeptidase inhibitor	0.67^a	11.92 ± 1.63	11.91 ± 1.69	0.67^c
6754164	complement C5 preproprotein	endopeptidase inhibitor	1.81	4.02 ± 0.45	3.96 ± 0.80	1.79^c
161086891	complement component 6 precursor	immune response	1.72	5.52 ± 0.57	6.53 ± 0.43^b	2.03^c
345110552	complement component C7 precursor	immune response	0.76	1.49 ± 0.16	1.67 ± 0.05	0.85
22122667	complement component C8 alpha chain isoform 1 precursor	complement activation	1.51	4.90 ± 0.22	4.19 ± 0.22	1.55
15375312	complement component C9 precursor	complement activation	1.81	6.59 ± 0.73	7.60 ± 0.49^b	2.09^c
568986620	clusterin isoform X2 (ApoJ)	misfolded protein binding	1.04	12.40 ± 1.25	14.63 ± 1.63^b	1.23
Antioxidants
261823995	serum paraoxonase/arylesterase 1 precursor	antioxidant	0.67	1.54 ± 0.20	1.44 ± 0.23	0.63^c
15011841	glutathione peroxidase 3 precursor	antioxidant	0.65	2.23 ± 0.24	2.50 ± 0.53	0.73
Lipid Metabolism
160333304	apolipoprotein A-I preproprotein	cholesterol transporter	0.68^a	4.64 ± 0.42	4.92 ± 0.45	0.72^c
157951676	apolipoprotein A-II precursor	cholesterol transporter	1.18	5.58 ± 0.62	4.12 ± 0.32^b	0.87
244791354	phosphatidylcholine-sterol acyltransferase	phosphatidylcholine-sterol O- acyltransferas	1.03	5.76 ± 0.80	5.08 ± 0.46	1.36
568915857	phospholipid transfer protein isoform X1	lipid binding	1.96	2.90 ± 0.51	3.63 ± 1.14	2.46^c
158517825	apolipoprotein C-I precursor	fatty acid binding	1.51	6.92 ± 0.95	7.84 ± 0.81	1.34
577019552	apolipoprotein C-III isoform a	lipid binding	0.84	6.59 ± 0.06	6.80 ± 0.99	0.87
110347473	apolipoprotein A-IV precursor	antioxidant, cholesterol transporter	1.21	8.34 ± 0.79	12.10 ± 0.71^b	1.75^c
163644329	apolipoprotein E precursor	antioxidant, cholesterol transporter	1.59	11.81 ± 1.09	13.25 ± 0.70^b	1.79^c
75677437	apolipoprotein D precursor	cholesterol binding	0.73	2.64 ± 0.13	2.79 ± 0.01	0.77
163310765	serum albumin precursor	DNA binding	0.78	0.80 ± 0.21	1.29 ± 0.36^b	1.25^c
7305599	transthyretin precursor	hormone binding	0.54^a	6.64 ± 0.10	6.02 ± 0.49	0.49^c
Vitamin Transport
125347464	afamin precursor	vitamin E binding	0.79	1.54 ± 0.23	3.63 ± 0.42^b	1.87^c
51172612	vitamin D-binding protein precursor	actin binding	0.83	6.95 ± 1.16	11.57 ± 0.92^b	1.38^c
33859612	retinol-binding protein 4 isoform 1	retinol binding	1.13	11.19 ± 1.33	17.63 ± 0.75	1.79
Acute Phase Response
76881807	alpha-1-antitrypsin 1–2 precursor	serine-type endopeptidase inhibitor	0.71^a	3.72 ± 0.65	3.07 ± 0.37^b	0.59^c
7304875	alpha-2-HS-glycoprotein isoform 1 (Fetuin A)	cysteine-type endopeptidase inhibitor	0.83	6.71 ± 0.78	7.21 ± 0.35	0.89
6755398	serum amyloid A-4 protein precursor	acute-phase response	0.50	6.55 ± 0.44	5.82 ± 0.22^b	0.45^c
110347564	ceruloplasmin isoform b precursor	copper ion binding	0.93	5.57 ± 0.65	6.41 ± 0.75	1.07
449083336	fibronectin isoform b precursor	peptidase activator	2.74^a	4.16 ± 0.55	4.12 ± 0.48	2.74^c
6753798	prothrombin precursor	thrombospondin receptor	0.87	5.27 ± 0.54	8.53 ± 1.39	1.41^c
156231029	kininogen 2 isoform 2 precursor	serine-type endopeptidase inhibitor	0.39^a	4.12	10.97 ± 1.64	0.41
160358829	hemopexin precursor	metal ion binding	1.24	2.99 ± 0.38	4.62 ± 0.40^b	1.92^c
8850219	haptoglobin precursor	hemoglobin binding	2.45	8.50 ± 1.11	23.04 ± 2.25^b	13.27^c
Immune Response
568999092	H-2 class I histocompatibility antigen, Q10 alpha chain isoform X1	peptide antigen binding	0.77	2.31 ± 0.09	5.66 ± 0.68^b	1.89
160415217	zinc-alpha-2-glycoprotein precursor	peptide antigen binding	1.31	5.84 ± 0.14	8.16 ± 0.16^b	1.83^c
170172530	immunoglobulin J chain precursor	antigen binding	1.93^a	5.15 ± 0.58	1.64 ± 0.01^b	0.61
Proteolysis
568910406	antithrombin-III isoform X1	serine-type endopeptidase inhibitor	0.52^a	4.53 ± 0.11	5.71 ± 0.21^b	0.66
257471003	plasminogen precursor	serine-type endopeptidase	0.81	6.60 ± 0.39	6.50 ± 0.30	0.80^c
236465805	plasma kallikrein precursor	serine-type endopeptidase	1.11	2.49 ± 0.25	2.52 ± 0.42	1.12
Proteolysis Inhibition
124249351	interalpha-trypsin inhibitor heavy chain H1 precursor	serine-type endopeptidase inhibitor	0.62	5.45 ± 0.40	4.77 ± 0.53	0.55^c
226874935	interalpha-trypsin inhibitor heavy chain H2 precursor	serine-type endopeptidase inhibitor	0.38^a	3.90 ± 0.31	4.21 ± 0.58	0.41^c
Proteolysis Inhibition
159110717	interalpha-trypsin inhibitor heavy chain H3 precursor	serine-type endopeptidase inhibitor	1.45	5.86 ± 1.26	6.82 ± 0.11	1.69
148747546	serine protease inhibitor A3K precursor	serine-type endopeptidase inhibitor	0.76^a	3.33 ± 0.54	3.50 ± 0.33	0.80
130503301	serine protease inhibitor A3N precursor	serine-type endopeptidase inhibitor	1.15	1.97 ± 0.32	2.87 ± 0.57^b	1.39
31982171	murinoglobulin-1 precursor	serine-type endopeptidase inhibitor	0.94	2.67 ± 0.52	2.11 ± 0.31	0.75^c
Metal Binding
20330802	serotransferrin precursor	ferric iron binding	0.80	2.61 ± 0.35	2.62 ± 0.37	0.80^c
17647499	hemoglobin subunit beta-2	heme binding	2.44^a	0.13 ± 0.01	0.21 ± 0.02^b	3.85
226958456	histidine-rich glycoprotein precursor	cysteine-type endopeptidase inhibitor	1.28	2.49 ± 0.27	2.37 ± 0.38	1.21
Hemostasis
110347469	alpha-2-macroglobulin precursor	endopeptidase inhibitor	0.83^a	2.18 ± 0.29	2.21 ± 0.28	0.84^c
110625994	coagulation factor X isoform 2 preproprotein	calcium ion binding	3.58^a	5.65 ± 0.78	5.17 ± 0.86	3.27^c
Other Plasma Proteins
111378397	phosphatidylinositol-glycan-specific phospholipase D precursor	phospholipase D	0.78	3.42 ± 0.28	3.06 ± 0.06	0.70^c
28916693	gelsolin isoform 1 precursor	metal ion binding	0.79	6.52 ± 1.03	4.58 ± 0.73^b	0.55^c
16418335	leucine-rich alpha-2-glycoprotein precursor	transforming growth factor beta receptor binding	0.99	4.07 ± 0.10	6.57 ± 0.30^b	1.59

Significant difference in NSAF (P < 0.05).

Significant difference in k (P < 0.05).

Significant difference in RPR (P < 0.05).