Table 3.

SNP and InDel distribution in amino acid biosynthetic pathway

Strains	Production	Ref. genome	SNP and InDel in genes	Gene description
ATCC21300	lysine	ATCC13032	ppc: upstream -1 A deletion; ……	ppc: phosphoenolpyruvate carboxylase
B253	lysine	B1	lysC: p.Leu329_Gln330del (inframe deletion), p.Gly359Asp; hom: p.Gln399* stop gained	lysC: Aspartokinase hom: Homoserine dehydrogenase
ATCC21493	arginine	ATCC14067	KIQ_011285: p.Gly159Asp; KIQ_013990: p.Arg390Cys; KIQ_009960: Ala701Thr p.Ala378Thr	KIQ_011285: arginine repressor KIQ_013990: glutamate_dehydrogenase odhA(KIQ_009960): 2-oxoglutarate dehydrogenase E1/E2 component
SYPS-062	serine	ATCC14067	KIQ_000725: p.Leu103Phe; KIQ_012535: p.Glu251Lys, p.Arg422Gln; KIQ_009375: p.Asp394Asn; KIQ_009610: upstream-9 C->T	KIQ_000725: serine acetyltransferase KIQ_012535: serine dehydratase KIQ_009375: serine_hydroxymethyltransferase KIQ_009610: phosphoglycerate mutase KIQ_014800: pyruvate dehydrogenase E1
SYPS-062-33a	serine	ATCC14067	KIQ_000725: p.Leu103Phe; KIQ_012535: p.Glu251Lys, p.Arg422Gln; KIQ_009375: p.Asp394Asn; KIQ_009610: upstream-9 C->T; KIQ_014800: p.His594Tyr
ATCC15168	isoleucine	ATCC14067	KIQ_005265: p.Ser248Phe; KIQ_012240: p.Gly186Arg	KIQ_005265:2-isopropylmalate synthase; KIQ_012240: phosphoenolpyruvate carboxylase
MT	arginine	AS1.542	argR: p.Gln37*stop gained; odhA: p.Ala170Thr; argC; p.Gly134Glu	argR Arginine repressor argC: N-acetyl-gamma-glutamyl-phosphate reductase argG: Argininosuccinate synthase argF: Ornithine carbamoyltransferase odhA: 2-oxoglutarate dehydrogenase E1/E2 component
SYPA5-5	arginine	AS1.542	argR: p.Gln37* stop gained; odhA: p.Ala170Thr; argC: p.Gly134Glu, p.Asp123Asn; argG: p.Ile219Thr; argF: p.Ala191fs
SCgG1	glutamate	T6-13	dapA: p.Glu293Lys; ppc: p.Ala433Thr	dapA: 4-hydroxy-tetrahydrodipicolinate synthase ppc: phosphoenolpyruvate carboxylase ykuT(yggB): putative MscS family protein YkuT aceF: Dihydrolipoyllysine-residue acetyltransferasecomponent of pyruvate dehydrogenase complex
SCgG2	glutamate	T6-13	dapA: p.Glu293Lys; ppc: p.Ala433Thr
Z188	glutamate	T6-13	dapA: p.Glu293Lys; ppc: p.Ala433Thr; ykuT: p.Glu350Lys
S9114	glutamate	T6-13	dapA: p.Glu293Lys; ppc: p.Ala433Thr; ykuT: p.Glu350Lys; aceF: p.Glu216Asp, p.Glu344Gln, p.Lys365 Pro369del