Table 3. One and three-year transplant outcomes by ART regimen °.
N
(%) |
Patient survival | Death-censored graft
survival † |
Biopsy-proven acute
rejection |
Severe
infection † |
|||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1y | p | 3y | p | 1y | p | 3y | p | 1y | p | 3y | p | 6m | p | ||
Overall | 58 | 91.4 | 89.7 | 93.1 | 89.7 | 13.8 | 17.2 | 26.3 | |||||||
TDF | |||||||||||||||
Yes | 19 | 89.5 | 89.5 | 94.7 | 94.7 | 15.8 | 10.5 | 31.6 | |||||||
No * | 35 | 94.3 | 0.6 | 91.4 | >0.99 | 91.4 | >0.99 | 85.7 | 0.4 | 14.3 | >0.99 | 22.9 | 0.4 | 23.5 | 0.52 |
NRTI | |||||||||||||||
Yes | 54 | 92.6 | 90.7 | 92.6 | 88.9 | 14.8 | 18.52 | 26.4 | |||||||
No | 4 | 75 | 0.3 | 75 | 0.36 | 100 | >0.99 | 100 | >0.99 | 0 | >0.99 | 0 | >0.99 | 25 | |
NNRTI | |||||||||||||||
Yes | 14 | 100 | 100 | 92.9 | 92.9 | 7.14 | 21.4 | 7.14 | |||||||
No | 44 | 88.6 | 0.32 | 86.4 | 0.32 | 93.2 | >0.99 | 88.6 | >0.99 | 15.9 | 0.66 | 15.9 | 0.69 | 32.6 | 0.08 |
PI | |||||||||||||||
Yes | 33 | 84.5 | 81.8 | 87.9 | 81.8 | 21.2 | 18.2 | 39.4 | |||||||
No | 25 | 100 | 0.06 | 100 | 0.03 | 100 | 0.12 | 100 | 0.03 | 4 | 0.12 | 16 | >0.99 | 8.33 | 0.01 |
INSTI | |||||||||||||||
Yes | 24 | 95.8 | 95.8 | 100 | 100 | 8.33 | 8.33 | 21.7 | |||||||
No | 34 | 88.2 | 0.39 | 85.3 | 0.38 | 88.2 | 0.13 | 82.4 | 0.04 | 17.7 | 0.45 | 23.5 | 0.17 | 29.4 | 0.5 |
Two drug regimens ˆ | |||||||||||||||
NRTI + INSTI | 12 | 100 | 100 | 100 | 100 | 8.3 | 8.3 | 18.1 | |||||||
NRTI + NNRTI | 9 | 100 | 100 | 100 | 100 | 0 | 11.1 | 0 | |||||||
NRTI + PI | 23 | 82.6 | 0.16 | 78.3 | 0.1 | 86.9 | 0.41 | 78.3 | 0.1 | 21.7 | 0.36 | 21.7 | 0.65 | 39.1 | 0.07 |
NRTI + other * | 21 | 100 | 100 | 100 | 100 | 4.8 | 9.5 | 10 | |||||||
NRTI + PI | 23 | 82.6 | 0.11 | 78.3 | 0.05 | 86.9 | 0.23 | 78.3 | 0.05 | 21.7 | 0.19 | 21.7 | 0.42 | 39.1 | 0.04 |
ART, antiretroviral therapy; INSTI, integrase strand transfer inhibitors; NRTI, nucleoside reverse transcriptase inhibitors; NNRTI, non-nucleoside reverse transcriptase inhibitors; PI, protease inhibitors; TDF, tenofovir disoproxil fumarate.
ºRefers to the ART regimen the patient was discharged home with after the initial transplant hospitalization.
P values correspond to Fisher 's exact test. Numbers in bold represent statistical significance.
†As defined previously 4. See main text for details.
ˆRegimens listed here were three most common ART regimens post-transplant in this cohort.
*Includes NRTI + INSTI and NRTI + NNRTI.