Fig. 3.

Models 1, 2, and 3. a Model 1 of a random distribution of dynamic proteins. All the proteins are freely moving and only interact by random “hit-and-run” mechanism. b Model 2 of stable metabolons. This model involves pre-formed metabolons that are exchanged to the POR acting as a charging station. c Models 3a, b and c of proteins organized in large structures. Model 3a, proteins organized in highways across the ER tubule with POR trapped inside the highways. Model 3b, proteins organized in highways across the ER tubule with POR freely moving around the highways. Model 3c, proteins organized in aggregates with freely moving POR