Table 2.

Effect of traxoprodil on the concentration of antidepressants in mouse brain

Treatment (mg/kg)		Antidepressants concentration in brain (ng/g)
(A)	Desipramine 10 + saline	1649 ± 96.15
	Desipramine 10 + traxoprodil 10	2217 ± 293.1
(B)	Paroxetine 0.5 + saline	140.0 ± 8.823
	Paroxetine 0.5 + traxoprodil 10	150.5 ± 8.733
(C)	Milnacipran 1.25 + saline	410.6 ± 80.60
	Milnacipran 1.25 + traxoprodil 10	337.7 ± 38.28
(D)	Bupropion 10 + saline	965.7 ± 74.02
	Bupropion 10 + traxoprodil 10	1566 ± 249.6**

Antidepressants and traxoprodil were administered i.p. 60 min before decapitation. Each experimental group consisted of 10 animals. Results are presented as mean values ± SEM. The results were considered statistically significant if p < 0.05

** p < 0.01 compared with the respective control group (Student’s t test)