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. 2016 Sep 23;44(1):79–88. doi: 10.1007/s11033-016-4082-z

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Lipid accumulation in foam cells transfected with different miRNA oligonucleotides and their secreted levels of miR-33a and ABCA1 in foam cell culture media. The five types of cells differently treated or transfected with miRNA oligonucleotides and stained with oil red O afterwards showed different levels of lipid accumulations. Moderate staining intensity in Ox-LDL-treated control foam cells (a), very low staining intensity in non-LDL treated macrophages (b), strong staining intensity in foam cells transfected with miR-33a-mimic (c), moderate intensities in foam cells transfected with anti-miR-33a and miR-33a-mismatched, respectively(d–e). Supernatant miR-33a level of foam cells that are transfected with miR-33a-mimic was 5.7-fold higher than that of control group (f). Supernatant ABCA1 level of cells transfected with miR-33a-mimic decreased 0.43-fold of that of control group, while those of cells transfected with anti-miR33a and miR-33a-mismatched were 1.69- and 1.75-fold higher than that in the control group, respectively (g)