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. 2016 Feb 3;54(2):1352–1368. doi: 10.1007/s12035-016-9716-6

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Behavior tests in an open field. Tg ^+/− mice display GABA receptor-mediated increased locomotor activity. a Traces of locomotion in an open field show significant hyperactivity and circling of Tg ^+/− mice. b Motor coordination of WT (n = 6) and Tg ^+/− (n = 3) mice on the accelerating rotarod was analyzed in three trials/session (repeated measures ANOVA: genotype effect, ***P < 0.0001; session effect, *P < 0.0117). The values represent means of three trials/session ± SEM. c Quantification of mouse locomotion in an open field showing that picrotoxin significantly reduced hyperactivity of mutants (n = 6 Tg ^+/−, n = 5 WT) but did not correct circling. There was a significant alleviation of the locomotor activity of Tg ^+/− mice compared to WT after the application of haloperidol-decanoate at 48 h. Data represent mean ± SEM (**P < 0.01; ***P < 0.001)