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. 2016 Feb 3;54(2):1352–1368. doi: 10.1007/s12035-016-9716-6

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 7 — Changes in Purkinje cells in the anterior lobe (detail of lobules I–II). a, b Purkinje cells (PCs) are oriented in a monolayer with dendrites projecting into the ML at P16, as visualized by calbindin staining (green; nuclear staining, blue). More calbindin-negative PCs are visible in the Tg ^+/− anterior lobe (b, arrows). The density of PC dendrites stained by calbindin is noticeably reduced in Tg ^+/− compared to WT (a) at P16. c, d A profound reduction of calbindin expression in PCs and PC dendrites in the ML progresses with increasing age in the Tg ^+/− anterior lobe (d), as visualized by lack of staining with anti-calbindin. Anti-NF200 staining (red) of basket interneuron fibers wrapped around Purkinje cell bodies (arrowheads) is still detected in 4-month-old Tg ^+/− mice. ML, molecular layer; PCL, PC layer; GCL, granule cell layer. Scale bar 200 μm (a–b), 100 μm (c, d)