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. 2016 Feb 3;54(2):1352–1368. doi: 10.1007/s12035-016-9716-6

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 8 — Reduction of Purkinje cell (PC) immunogenicity and apparent loss of PC dendrites in the molecular layer of the adult transgenic cerebella. PCs form a monolayer with dense network of dendrites in the ML throughout all the lobules in control cerebellum (a). At 6 months, a profound loss of calbindin expression in PCs and PC dendrites in the ML progresses in all lobules of the Tg ^+/− cerebella (b) as visualized by lack of staining with anti-calbindin (green). A near complete loss of calbindin expression in PCs and PC dendrites (arrows in d, f) is detected in the Tg ^+/− cerebella compared to WT, in detail shown in the lobules I–II and X (c, e). ML, molecular layer; PCL, PC layer; GCL, granule cell layer. Scale bar 1000 μm (a, b); 250 μm (c–f)