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. 2017 Feb 9;12:1113–1126. doi: 10.2147/IJN.S123228

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© 2017 Liu et al. This work is published and licensed by Dove Medical Press Limited

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Hematoxylin and eosin staining of frozen sections of thrombi after injection with the NPs after in vivo magnetic resonance imaging scanning was finished.

Notes: (A) Fe₃O₄-PLGA NPs and (B) Fe₃O₄-PLGA-cRGD NPs. A few of the Fe₃O₄-PLGA-cRGD NPs gathered on the surface of the thrombus, and many NPs were found under vascular endothelial cells (black arrows). No NPs were found in the sample injected with Fe₃O₄-PLGA NPs. These images are magnified ×200.

Abbreviations: cRGD, cyclic Arg-Gly-Asp; NPs, nanoparticles; PLGA, poly(lactic-co-glycolic acid).