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Pathologic hematoxylin and eosin staining (A–E) of the heart, liver, spleen, lung, and kidney. (A1–E1) before NP injection, (A2–E2) after injection of Fe3O4-PLGA NPs, and (A3–E3) after injection of Fe3O4-PLGA-cRGD NPs. There was no evidence of inflammatory reactions or necrosis in the two groups, and no abnormal cell morphology was found. The magnification is 400×.
Abbreviations: cRGD, cyclic Arg-Gly-Asp; NPs, nanoparticles; PLGA, poly(lactic-co-glycolic acid).
