Table 2.

Blood chemistry parameters of rats injected with Fe₃O₄-based PLGA nanoparticles

	1 h	3 h	24 h	3 d	7 d
GPT (20–61 U/L)*
Fe3O4-PLGA	65.50±2.64**	65.50±3.32**	45.50±3.11	47.50±12.4	44.70±14.86
Fe3O4-PLGA-cRGD	64.50±2.65**	65.75±4.92**	44.74±2.06	47.75±13.37	47.25±11.53
GOT (39–111 U/L)*
Fe3O4-PLGA	132.00±14.24**	122.70±22.29**	94.50±16.98	93.50±14.48	89.00±11.05
Fe3O4-PLGA-cRGD	122.50±8.02**	117.00±14.49**	92.50±15.55	95.50±13.20	88.00±10.86
Total bilirubin (2–12 μmol/L)*
Fe3O4-PLGA	4.50±1.29	3.50±1.29	4.50±1.29	4.25±1.50	4.50±1.29
Fe3O4-PLGA-cRGD	3.50±0.58	4.25±1.25	4.00±1.41	4.25±1.50	3.75±0.96
Creatinine (4–57 μmol/L)*
Fe3O4-PLGA	33.75±3.10	30.75±5.32	30.25±3.30	32.50±4.92	37.00±11.66
Fe3O4-PLGA-cRGD	34.25±1.50	33.25±5.56	33.25±3.77	34.75±4.57	37.00±6.73
Urea (3.2–7.5 mmol/L)*
Fe3O4-PLGA	5.75±0.96	6.42±0.90	4.50±1.15	5.45±1.62	6.92±0.46
Fe3O4-PLGA-cRGD	6.00±0.60	5.98±0.67	5.55±0.86	5.85±1.14	6.43±0.72

Notes:

^*The remaining indicators are within normal ranges.

^**GPT and GOT increased slightly within 1 and 3 h, but returned to normal at the 24 h, 3 d, and 7 d time points after injection in the two groups.

Abbreviations: cRGD, cyclic Arg-Gly-Asp; GPT, glutamic pyruvic transaminase; GOT, glutamic oxaloacetic transaminase; PLGA, poly(lactic-co-glycolic acid).