Table 2. Top 10 association meta-analysis results for gait speed.
Screening Set (n=31,478) | Validation Set (n=2,588) | Screening + Validation Set (n=34,066) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
SNP | Chr.:Position | E/NE Allele | F E Allele | Closest Gene | Δ(kb)/gene location | Beta (SE) | P | HetPVal | Beta (SE) | P | Beta (SE) | P |
rs17527406 | 6:33709545 | C/G | 0.016 | UQCC2(MNF1) | intron | 0.040(0.007) | 5.22E-7 | 0.2669 | 0.014(0.032) | 0.65 | 0.037(0.007) | 6.883e-7 |
rs9501255* | 6:33087321 | T/C | 0.038 | HLA-DPB1 | 3′ UTR | 0.023(0.005) | 1.53e-6 | 0.5853 | 0.048(0.023) | 0.04 | 0.024(0.005) | 3.326e-7 |
rs7763822* | 6:33092651 | T/C | 0.038 | HLA-DPB1 | 3 | 0.023(0.005) | 1.54e-6 | 0.5704 | 0.047(0.023) | 0.04 | 0.024(0.005) | 3.440e-7 |
rs3749985* | 6:33086656 | C/G | 0.038 | HLA-DPB1 | 3′ UTR | 0.023(0.005) | 1.55e-6 | 0.5856 | 0.048(0.023) | 0.04 | 0.024(0.005) | 3.385e-7 |
rs7746199# | 6:27293545 | C/T | 0.166 | POM121L2 | 15 | 0.011(0.002) | 1.58E-6 | 0.9658 | 0.011(0.008) | 0.19 | 0.011(0.002) | 7.125e-7 |
rs12155739 | 8:102084750 | C/T | 0.030 | NCALD | intron | −0.041(0.008) | 2.04E-6 | 0.2076 | −0.024(0.032) | 0.45 | −0.039(0.008) | 1.858e-6 |
rs3800318# | 6:27295862 | A/T | 0.830 | POM121L2 | 13 | −0.011(0.002) | 2.07E-6 | 0.966 | −0.011(0.008) | 0.20 | −0.011(0.002) | 9.686e-7 |
rs13211166 | 6:27298161 | A/T | 0.190 | POM121L2 | 11 | 0.011(0.002) | 2.12E-6 | 0.9688 | 0.010(0.009) | 0.24 | 0.010(0.002) | 1.136e-6 |
rs9403969 | 6:148622038 | T/G | 0.737 | SASH1 | 70 | 0.009(0.002) | 2.34e-6 | 0.4004 | 0.005(0.007) | 0.50 | 0.009(0.002) | 2.351e-6 |
rs16897515# | 6:27310241 | A/C | 0.161 | POM121L2 | missense | 0.011(0.002) | 2.41E-6 | 0.9505 | 0.007(0.009) | 0.42 | 0.010(0.002) | 2.080e-6 |
*First gene segment, #second gene segment. E/NE-Effect-, Non-Effect allele; F E-Frequency of Effect Allele; Δ-distance to proximal gene; HetPVal- Heterogeneity P Value.