Table 2.
Heritability (Estimate ± SE [95% Confidence Interval]) of Bone Microarchitecture and Density Traits
| Trait | Model 1 | Model 2 | Model 3 |
|---|---|---|---|
| Radial bone | |||
| Ultradistal radius DXA aBMD |
0.465 ± 0.117 [0.228, 0.729] |
0.417 ± 0.117 [0.184, 0.624] |
— |
| Total density (mg/cm3 HA) | 0.743 ± 0.117 [0.498, 0.949] |
0.650 ± 0.123 [0.407, 0.880] |
0.613 ± 0.125 [0.307, 0.823] |
| Cortical thickness (mm) | 0.611 ± 0.117 [0.381, 0.875] |
0.545 ± 0.129 [0.313, 0.743] |
0.504 ± 0.140 [0.117, 0.719] |
| Cortical area fraction (Ct.Ar/Tt.Ar) |
0.697 ± 0.119 [0.408, 0.881] |
0.593 ± 0.127 [0.377, 0.816] |
0.535 ± 0.132 [0.308, 0.825] |
| Cortical density (mg/cm3 HA) |
0.828 ± 0.135 [0.482, 1.000] |
0.733 ± 0.142 [0.438, 0.998] |
0.644 ± 0.152 [0.341, 0.929] |
| Cortical porosity (%) | 0.278 ± 0.216 [0.0, 0.780] |
0.244 ± 0.215 [0.0, 0.718] |
0.227 ± 0.215 [0.0, 0.721] |
| Trabecular density (mg/cm3 HA) |
0.646 ± 0.142 [0.372, 0.903] |
0.623 ± 0.143 [0.367, 0.897] |
0.443 ± 0.151 [0.080, 0.690] |
| Trabecular number (mm−1) | 0.193 ± 0.162 [0.0, 0.413] |
0.184 ± 0.161 [0.0, 0.414] |
0.082 ± 0.166 [0.0, 0.357] |
| Trabecular thickness (mm) | 0.414 ± 0.160 [0.048, 0.749] |
0.397 ± 0.160 [0.018, 0.715] |
0.319 ± 0.153 [0.006, 0.615] |
| Tibial bone | |||
| Total density (mg/cm3 HA) | 0.803 ± 0.108 [0.514, 1.000] |
0.743 ± 0.114 [0.485, 1.000] |
— |
| Cortical thickness (mm) | 0.917 ± 0.110 [0.654, 1.000] |
0.835 ± 0.121 [0.478, 0.998] |
— |
| Cortical area fraction (Ct.Ar/Tt.Ar) |
0.983 ± 0.097 [0.728, 1.000] |
0.895 ± 0.108 [0.582, 1.000] |
— |
| Cortical density (mg/cm3 HA) |
0.711±0.127 [0.392,0.931] |
0.638±0.135 [0.353,0.878] |
— |
| Cortical porosity (%) | 0.526 ± 0.140 [0.270, 0.733 |
0.509 ± 0.142 [0.215, 0.709] |
— |
| Trabecular density (mg/cm3 HA) |
0.554 ± 0.111 [0.430, 0.861] |
0.561 ± 0.111 [0.325, 0.777] |
— |
| Trabecular number (mm−1) | 0.595±0.142 [0.302,0.879] |
0.600±0.152 [0.274,0.893] |
— |
| Trabecular thickness (mm) | 0.519 ± 0.132 [0.225, 0.790] |
0.480 ± 0.134 [0.202, 0.752] |
— |
Model 1: adjusted for sex and age and estrogenic status (women).
Model 2: Model 1 plus height and weight.
Model 3: Model 2 plus UD radial aBMD.