Table 1.
Target | Biological process | Resistance/sensitivity | Reference |
---|---|---|---|
EGFR | Angiogenesis, survival, and proliferation | Gefitinib, TKI | 92,96 |
BCL-2 | Apoptosis | Platinum | 90 |
PTEN | Proliferation | Gefitinib, cisplatin | 56,91 |
Caspase-8, TRAF-7 | Inhibition of NF-κB activation | TRAIL | 94 |
Abbreviations: TKI, tyrosine kinase inhibitor; PTEN, Phosphatase and tensin homolog; EGFR, epidermal growth factor receptor; BCL-2, B-cell lymphoma 2.