Table 1.

miR-21 controls key biological processes driving to tumorigenesis and therapeutic response in lung cancer

Target	Biological process	Resistance/sensitivity	Reference
EGFR	Angiogenesis, survival, and proliferation	Gefitinib, TKI	92,96
BCL-2	Apoptosis	Platinum	90
PTEN	Proliferation	Gefitinib, cisplatin	56,91
Caspase-8, TRAF-7	Inhibition of NF-κB activation	TRAIL	94

Abbreviations: TKI, tyrosine kinase inhibitor; PTEN, Phosphatase and tensin homolog; EGFR, epidermal growth factor receptor; BCL-2, B-cell lymphoma 2.