. 2016 Aug 24;7:99–110. doi: 10.2147/LCTT.S107560

Table 4.

Univariate Cox hazard analysis of factors associated with overall survival after first-line chemotherapy

Factors	Univariate			Multivariate

	HR	95% CI	P	HR	95% CI	P
Age (years)
<75 vs ≥75	0.91	0.54–1.53	0.72
Sex
Male vs female	0.62	0.30–1.26	0.18
ECOG PS
0–1 vs 2–4	2.50	1.52–4.12	<0.01	2.54	1.46–4.42	<0.01
Stage
<IIIB vs IV	1.53	0.94–2.49	0.09	1.60	0.93–2.75	0.09
BMI (kg/m²)
≥18.5 vs <18.5	1.35	0.75–2.44	0.31
Leukocyte (×10³ cells/μL)	1.08	1.00–1.16	0.07
Neutrophil (×10³ cells/μL)^a	1.11	1.02–1.20	0.01	1.04	0.93–1.15	0.50
Lymphocyte (×10³ cells/μL)^a	0.61	0.40–0.92	0.02	0.67	0.42–1.07	0.09
Monocyte (×10² cells/μL)^a	1.18	1.06–1.32	<0.01	1.14	0.98–1.33	0.09
Hemoglobin (mg/dL)	0.88	0.75–1.03	0.10	0.90	0.74–1.10	0.31
Red cell distribution width (%)	1.02	0.83–1.25	0.87
Platelet (×10⁵ cells/μL)	1.23	1.01–1.61	0.04	0.92	0.68–1.24	0.57
Serum sodium (mEq/L)	0.96	0.91–1.02	0.21
LDH (×10² IU/L)	1.07	0.93–1.24	0.35
ALP (×10² IU/L)	1.41	1.10–1.81	<0.01	1.12	0.84–1.48	0.45
CRP (mg/dL)	1.11	1.05–1.17	<0.01	1.03	0.95–1.13	0.45

Notes: Coded as 1 (age ≥75 years, female, ECOG PS 2–4, stage IV, BMI <18.5 kg/m²) and as 0 (age <75 years, male, ECOG PS 0–1, stage I–III, BMI ≥18.5 kg/m²).

There was a significant correlation between neutrophil and monocyte counts (r=0.56, 95% CI 0.41–0.68, P<0.01), while no significant correlation was found between neutrophil and lymphocyte counts (r=0.02, 95% CI –0.17 to 0.22, P=0.81) and between lymphocyte and monocyte counts (r=0.12, 95% CI –0.08 to 0.31, P=0.23).

Abbreviations: ALP, alkaline phosphatase; BMI, body mass index; CI, confidence interval; CRP, C-reactive protein; ECOG, Eastern Cooperative Oncology Group; HR, hazard ratio; LDH, lactate dehydrogenase; PS, performance status.