. 2016 Aug 24;7:99–110. doi: 10.2147/LCTT.S107560

Table 6.

Univariate Cox hazard analysis of factors associated with overall survival after third-line chemotherapy

Factors	Univariate			Multivariate

	HR	95% CI	P	HR	95% CI	P
Age (years)
<75 vs ≥75	0.96	0.40–2.32	0.93
Sex
Male vs female	0.64	0.19–2.19	0.48
ECOG PS
0–1 vs 2–4	4.86	1.84–12.8	<0.01	9.48	2.68–33.6	<0.01
Stage
<IIIB vs IV	2.16	0.74–6.30	0.16
BMI (kg/m²)
≥18.5 vs <18.5	2.04	0.88–4.76	0.10	4.89	1.61–14.9	<0.01
Leukocyte (×10³ cells/μL)	1.10	0.94–1.30	0.24
Neutrophil (×10³ cells/μL)	1.15	0.97–1.37	0.12
Lymphocyte (×10³ cells/μL)	0.76	0.41–1.42	0.39
Monocyte (×10² cells/μL)	1.03	0.88–1.21	0.68
Hemoglobin (mg/dL)^a	0.80	0.64–1.00	0.05	0.70	0.51–0.95	0.02
Red cell distribution width (%)^a	1.31	1.03–1.67	0.03	1.00	0.75–1.34	0.99
Platelet (×10⁵ cells/μL)	1.23	0.86–1.77	0.26
Serum sodium (mEq/L)	0.97	0.84–1.12	0.69
LDH (×10² IU/L)	2.01	0.98–4.12	0.06	2.79	1.22–6.38	0.01
ALP (×10² IU/L)	1.03	0.52–2.05	0.94
CRP (mg/dL)	1.05	0.95–1.15	0.37
Interval between first- and third-line chemotherapy (months)^b	0.96	0.92–1.01	0.13
Interval between second- and third-line chemotherapy (months)^c	0.96	0.90–1.02	0.17

Notes: Coded as 1 (age ≥75 years, female, ECOG PS 2–4, stage IV, BMI <18.5 kg/m²) and as 0 (age <75 years, male, ECOG PS 0–1, stage I–III, BMI ≥18.5 kg/m²).

There was a significant inverse correlation between hemoglobin and red cell distribution width (r=−0.51, 95% CI −0.73 to −0.20, P<0.01).

From the start of first-line chemotherapy to the start of third-line chemotherapy.

From the start of second-line chemotherapy to the start of third-line chemotherapy.

Abbreviations: ALP, alkaline phosphatase; BMI, body mass index; CI, confidence interval; CRP, C-reactive protein; ECOG, Eastern Cooperative Oncology Group; HR, hazard ratio; LDH, lactate dehydrogenase; PS, performance status.