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Schematic showing signaling pathways downstream of EphB4 regulate vascular remodeling. MMP2/9, matrix metalloproteinase 2/9; Src, proto-oncogene tyrosine-kinase kinase; Cav1, caveolin1; PI3K, phosphatidylinositol-3-kinase, eNOS, endothelial nitric oxide synthase; PKG, cGMP-dependent protein kinase; MEK, mitogen-activated protein kinase; MAPK, mitogen-activated protein kinase; Erk, extracellular signal-regulated kinases.
