TABLE 1.

Effects of EphB4 and ephrinB2 in Cancer, Bone, and Placental Physiology

Source (Cell line)	Findings	References
Cancers
Breast Cancer (MCF10-B4)	EphB4 overexpression enhances migration, invasion, and colony formation; ephrinB2 reverses these effects via a forward signaling pathway	Rutkowski et al., 2012
Prostate Cancer
(PC3, PC3M, DU145, ALVA31, LAPC-4, LNCaP, CWR22R)	EphB4 expression is high in PC3 and higher in its metastatic form, PC3M	Xia et al., 2005,
(22Rv1)	EphB4 overexpression enhances migration, invasion, and colony formation; ephrinB2 reverses these effects via a forward signaling pathway	Rutkowski et al., 2012
HNSCC (SCC-15)	Inhibition of EphB4 in tumor cells leads to reduced cell number, apoptosis and activation of the death receptor-caspase pathway	Masood et al., 2006
Melanoma (K1735, SW1, M2, P, C19, C23)	High EphB4 expression enhances metastatic and migratory potential	Yang et al., 2006
Kaposi’s Sarcoma	EphrinB2 is necessary for survival of KS cells	Masood et al., 2005
Angiosarcoma	Increased EphB4 expression	Dill et al., 2012
Skeletal System
Osx=LacZ+ precursor cells, Col1=LacZ+ mature osteoblasts	Osx=LacZ+ cells closely colocalized with cartilage-invading vessels	Maes et al., 2010
Placenta
(HIPEC-65, BeWo)	Expression of EphB4 and ephrinB2 is induced by hypoxia (HIPEC-65 and BeWo); induction of ephrinB2 expression is independent of HIF-1alpha (BeWo)	Chennakesava et al., 2006
Severe pre-eclamptic human placentas	Increased miR-17, miR-20a, and miR-20b expression	Wang et al., 2012
(HUVEC, BeWo)	Inhibition of miR-20b expression increased IF1A, MMP2, ephrinB2 and EphB4 expression