Table 1.
Top ten elements of the analysis. The proteins are ranked based on degree values. By considering BC≥0.05 and the hub proteins are introduced as hub-bottlenecks (the correspond gene names are asterisked in the table). Four clusters are determined in the network and the key proteins are organized in the two clusters 1 and 2.
| Row | Gene Name | Protein Name | Disease Score | Degree | BC | Cluster No. |
|---|---|---|---|---|---|---|
| 1 | *STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) |
3.98 | 25 | 0.11 | 2 |
| 2 | *NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
3.60 | 23 | 0.11 | 1 |
| 3 | *CD40 | CD40 molecule, TNF receptor superfamily member 5 tumor necrosis factor |
3.76 | 21 | 0.11 | 1 |
| 4 | * TNFA | necrosis factor | 3.63 | 20 | 0.08 | 1 |
| 5 | IL10 | interleukin 10 | 4.30 | 19 | 0.04 | 2 |
| 6 | *TYK2 | tyrosine kinase 2 | 3.49 | 19 | 0.05 | 1 |
| 7 | *NOD2 nucl | eotide-binding oligomerization domain containing 2 | 5.00 | 18 | 0.11 | 1 |
| interleukin 23 receptor | ||||||
| 8 | *IL23R | interleukin 1, beta | 5.00 | 18 | 0.06 | 1 |
| 9 | IL1B | interferon, gamma | 3.09 | 18 | 0.02 | 1 |
| 10 | IFNG | 4.03 | 16 | 0.04 | 1 |