Table 2.

Changes in brain parenchymal volumes in relation to serum NT-proBNP

	Serum NT-proBNP (ng/L)
	Low N=812 5–87.7	Middle N=796 87.8–179.4	High N=822 179.5–4795	Beta* (95% CI)	P-value
Δ Total brain volume, ml, mean (SE)
Model-1	−38.1 (0.7)	−40.3 (0.7)	−41.0 (0.7)	−3.9 (−6.0, −1.8)	<0.001
Model-2	−41.3 (1.7)	−43.8 (1.7)	−44.0 (1.7)	−3.6 (−6.0, −1.1)	0.004
Δ Grey matter volume, ml, mean (SE)
Model-1	−14.7 (0.6)	−16.4 (0.6)	−16.7 (0.7)	−3.7 (−5.6, −1,8)	<0.001
Model-2	−17.5 (1.6)	−19.6 (1.6)	−19.6 (1.6)	−3.5 (−5.7, −1.3)	0.001
Δ White matter volume, ml, mean (SE)
Model-1	−23.1 (0.4)	−23.9 (0.4)	−24.7 (0.4)	−1.1 (−2.3, 0.18)	0.093
Model-2	−27.2 (1.1)	−27.3 (1.1)	−27.8 (1.0)	−0.3 (−1.7, 1.1)	0.659

Abbreviations: SE: standard error

^*Beta (95% CI) and p-values are calculated using the continuous value of log-transformed NT-proBNP levels

Δ: Second measure - First measure

Model-1: adjusted for age, sex and baseline brain volumes

Model-2: adjusted for age, sex, baseline brain volumes, education, current smoker, hypertension (medical records or antihypertensive medication), diabetes mellitus, systolic blood pressure, coronary heart disease, stroke, total cholesterol, body mass index, atrial fibrillation and glomerular filtration rate

All the analyses are adjusted for intracranial volumes and coil type.