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. Author manuscript; available in PMC: 2017 Feb 15.
Published in final edited form as: J Huntingtons Dis. 2016 Oct 1;5(3):217–237. doi: 10.3233/JHD-160205

Table 1.

Redox modifications of transcriptional players

Transcriptional players Redox targets Consequences References
SoxS (Bacteria) Fe-S cluster Changes in the activity of SoxS [70]
OxyR (Bacteria) Cys199 Changes in the activity of OxyR [160]
YAP1 (Yeast) Cys 598 and Csy620 in its NES terminal end Regulation of nuclear export [161, 174]
Ref-1 (Mammals) Cys 65 and Cys 93 in its N-terminal end Regulation of the redox states of TFs such as AP-1, NF-κB, p53, PAX5, PAX8, and Egr-1 [162]
AP-1 (Mammals) Cys residuse in basic region of Fos and Jun Changes in its DNA binding activity [179, 180]
NF-κB (Mammals) Cys62 of p50 sub-unit Changes in its DNA binding activity [138, 141]
p53 (Mammals) Multiple Cys residues Changes in its DNA binding activity [80]
PAX5 and PAX8 (Mammals) Cyst37 and Cys49 in Prd domain Changes in its DNA binding activity [40, 181]
Egr-1 (Mammals) Cys residues in zinc finger domain Changes in its DNA binding activity [41]