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. Author manuscript; available in PMC: 2017 Feb 15.
Published in final edited form as: Nat Microbiol. 2016 Nov 21;2:16216. doi: 10.1038/nmicrobiol.2016.216

Figure 4. Contribution of Wolbachia to O. volvulus in purine metabolism.

Figure 4

Inhibitors 8-amino-5′-deoxy-5′chloroguanosine and (−)-epicatechin (shown in the figure) have been found against the activities of purine nucleoside phosphorylase (EC 2.4.2.1) and ribonucleoside diphosphate reductase (EC 1.17.4.1)113,114. The chemical structures of the inhibitors shown were obtained from the Braunschweig Enzyme Database (BRENDA)115. Metabolites in bold represent biomass components.