Table 2. Multivariable logistic regression models to assess potential predictors of overall diagnostic inaccuracy, FP and FN of ICD-10 Clostridium Difficile code A047 in comparison with laboratory diagnosis of Clostridium difficile infections.
| Predictor | Overall Diagnostic Inaccuracy | FP | FN | |||
|---|---|---|---|---|---|---|
| OR | 95% CI | OR | 95% CI | OR | 95% CI | |
| IBD | 2.40 | 1.78–3.24 | 4.09 | 2.47–6.77 | 1.82 | 1.24–2.66 |
| No IBD | Reference | |||||
| Male | 1.04 | 0.78–1.39 | 1.22 | 0.74–2.01 | 0.97 | 0.68–1.37 |
| Female | Reference | |||||
| Age at index hospitalization (yrs) | ||||||
| <50 | 0.45 | 0.29–0.71 | 0.51 | 0.22–1.20 | 0.43 | 0.25–0.73 |
| 50–80 | 0.70 | 0.55–0.99 | 0.49 | 0.49–1.73 | 0.62 | 0.41–0.94 |
| >80 | Reference | |||||
| CCI score | ||||||
| 0 | Reference | |||||
| 1 | 0.90 | 0.57–1.42 | 0.81 | 0.34–1.95 | 0.94 | 0.55–1.60 |
| >1 | 1.45 | 1.00–2.11 | 1.71 | 0.87–3.33 | 1.35 | 0.86–2.12 |
| First hospitalization | Reference | |||||
| Second or later hospitalization | 2.25 | 1.56–3.24 | 3.61 | 1.72–7.61 | 1.89 | 1.24–2.89 |
| Rural hospital | 0.99 | 0.74–1.31 | 0.73 | 0.44–1.21 | 1.13 | 0.81–1.60 |
| Urban hospital | Reference | |||||
| SEFI | 0.99 | 0.89–1.10 | 1.01 | 0.85–1.20 | 0.98 | 0.87–1.11 |
| Era of hospitalization | ||||||
| 2005–07 | 1.82 | 1.28–2.58 | 1.87 | 1.04–3.38 | 1.81 | 1.18–2.79 |
| 2008–10 | 1.15 | 0.81–1.63 | 0.90 | 0.48–1.69 | 1.29 | 0.84–1.97 |
| 2011–14 | Reference | |||||
| c-statistic | 0.671 | 0.640 | 0.627 | |||
| Brier Score | 0.003 | 0.0009 | 0.002 | |||
FP: false positive; FN: false negative