Table 1. Effects on AGI and body weights in F1 and F3 generations.
Generation | Males | AGI (mm/g) | Body Weight (g) | Females | AGI (mm/g) | Body Weight (g) |
---|---|---|---|---|---|---|
F1 | Control (18) | 1.17 ± 0.05 | 1.34 ± 0.05 | Control (17) | 0.73 ± 0.03 | 1.30 ± 0.03 |
5 μg/kg (34) | 1.03 ± 0.02** | 1.37 ± 0.02 | 5 μg/kg (28) | 0.72 ± 0.02 | 1.31 ± 0.02 | |
40 μg/kg (28) | 1.03 ± 0.03 | 1.38 ± 0.02 | 40 μg/kg (37) | 0.65 ± 0.03 | 1.34 ± 0.02 | |
400 μg/kg (17) | 1.07 ± 0.03 | 1.31 ± 0.03 | 400 μg/kg (15) | 0.61 ± 0.05* | 1.37 ± 0.03 | |
F3 | Control (19) | 1.07 ± 0.03 | 1.31 ± 0.03 | Control (23) | 0.63 ± 0.02 | 1.32 ± 0.02 |
5 μg/kg (28) | 1.08 ± 0.02 | 1.29 ± 0.02 | 5 μg/kg (15) | 0.71 ± 0.02*** | 1.19 ± 0.03*** | |
400 μg/kg (16) | 1.02 ± 0.03 | 1.35 ± 0.03 | 400 μg/kg (22) | 0.64 ± 0.009 | 1.30 ± 0.02 |
Mean ± SEM. Number of pups per group in (). Data were collected on postnatal day 1.
*Significantly different from same-sex F1 control and 5 μg/kg groups, p<0.05.
**Significantly different from same-sex F1 control group, p<0.05.
***Significantly different from all other same-sex F3 groups, p<0.05.
Number of F1 litters per group: Control N = 6 litters, 5 μg/kg N = 10 litters, 40 μg/kg N = 10 litters, 400 μg/kg N = 6 litters. Number of F3 litters per group: Control lineage N = 9 litters, 5 μg/kg lineage N = 7 litters, 400 μg/kg lineage N = 6 litters.