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. 2017 Feb 15;12(2):e0171977. doi: 10.1371/journal.pone.0171977

Table 1. Effects on AGI and body weights in F1 and F3 generations.

Generation Males AGI (mm/g) Body Weight (g) Females AGI (mm/g) Body Weight (g)
F1 Control (18) 1.17 ± 0.05 1.34 ± 0.05 Control (17) 0.73 ± 0.03 1.30 ± 0.03
5 μg/kg (34) 1.03 ± 0.02** 1.37 ± 0.02 5 μg/kg (28) 0.72 ± 0.02 1.31 ± 0.02
40 μg/kg (28) 1.03 ± 0.03 1.38 ± 0.02 40 μg/kg (37) 0.65 ± 0.03 1.34 ± 0.02
400 μg/kg (17) 1.07 ± 0.03 1.31 ± 0.03 400 μg/kg (15) 0.61 ± 0.05* 1.37 ± 0.03
F3 Control (19) 1.07 ± 0.03 1.31 ± 0.03 Control (23) 0.63 ± 0.02 1.32 ± 0.02
5 μg/kg (28) 1.08 ± 0.02 1.29 ± 0.02 5 μg/kg (15) 0.71 ± 0.02*** 1.19 ± 0.03***
400 μg/kg (16) 1.02 ± 0.03 1.35 ± 0.03 400 μg/kg (22) 0.64 ± 0.009 1.30 ± 0.02

Mean ± SEM. Number of pups per group in (). Data were collected on postnatal day 1.

*Significantly different from same-sex F1 control and 5 μg/kg groups, p<0.05.

**Significantly different from same-sex F1 control group, p<0.05.

***Significantly different from all other same-sex F3 groups, p<0.05.

Number of F1 litters per group: Control N = 6 litters, 5 μg/kg N = 10 litters, 40 μg/kg N = 10 litters, 400 μg/kg N = 6 litters. Number of F3 litters per group: Control lineage N = 9 litters, 5 μg/kg lineage N = 7 litters, 400 μg/kg lineage N = 6 litters.