Table 2. Univariate and multivariable Cox regression models for overall survival to death.
| univariate | multivariable | |||||
|---|---|---|---|---|---|---|
| HR | 95%CI | p-value | HR | 95%CI | p-value | |
| Overall survival to death | ||||||
| Age (years) | 1,01 | 1,00–1,03 | *0,038 | 1,01 | 0,99–1,04 | 0,220 |
| Sex (male/female) | 0,93 | 0,57–1,50 | 0,761 | 0,97 | 0,59–1,59 | 0,899 |
| Histology | - | - | 0,727 | - | - | 0,927 |
| Chondrosarcoma | 0,78 | 0,39–1,56 | - | 0,93 | 0,45–1,95 | - |
| Ewing’s Sarcoma | 0,67 | 0,32–1,41 | - | 0,84 | 0,25–2,87 | - |
| Osteosarcoma | 0,90 | 0,42–1,96 | - | 1,10 | 0,42–2,90 | - |
| Margin (neg,/pos,) | 0,51 | 0,27–0,98 | 0,043 | 0,70 | 0,34–1,43 | 0,324 |
| Reconstruction | 0,92 | 0,57–1,49 | 0,744 | 1,30 | 0,73–2,29 | 0,373 |
| Grade (2 vs. 3)** | 2,27 | 1,21–4,26 | 0,001 | 3,04 | 1,41–6,57 | *0,005 |
| Tumorvolume (log2-transformed) | 1,12 | 01,00–1,25 | 0,060 | 1,18 | 1,03–1,34 | *0,014 |
*statistically significant
**Grade 1 excluded from analysis due to a low number of events
HR—hazard ratio; CI—confidence interval; neg.—negative; pos.–positive