Table 4. Bivariate correlations between serum 25OHD3, 1α,25(OH)2D3 and gene expression in skeletal muscle.
Data are Spearman correlation coefficients (rho)), with 95% confidence intervals (CI) and p values in brackets).
| Serum 25OHD3 | Serum 1α,25(OH)2D3 | |||||
|---|---|---|---|---|---|---|
| Gene | rho | 95% CI | p-value | rho | 95% CI | p-value |
| VDR | -0.41 | -0.64–-0.10 | 0.008 | -0.08 | -0.58–0.47 | 0.78 |
| mTOR | 0.06 | -0.22–0.33 | 0.68 | 0.22 | -0.26–0.61 | 0.36 |
| Atrogin1 | 0.08 | -0.20–0.34 | 0.58 | -0.24 | -0.62–0.24 | 0.32 |
| P300 | -0.08 | -0.35–0.20 | 0.58 | 0.24 | -0.24–0.62 | 0.32 |
| MuRF1 | 0.15 | -0.13–0.41 | 0.28 | -0.16 | -0.57–0.32 | 0.50 |
| Calpain1 | 0.16 | -0.11–0.42 | 0.23 | -0.03 | -0.48–0.43 | 0.88 |
| Calpain2 | 0.20 | -0.08–0.45 | 0.14 | -0.08 | -0.52–0.39 | 0.73 |
| USP19 | 0.27 | -0.01–0.50 | 0.05 | 0.12 | -0.36–0.54 | 0.63 |
| ATF-4 | 0.22 | -0.06–0.46 | 0.11 | -0.17 | -0.58–0.31 | 0.49 |
| Caspase3 | -0.22 | -0.47–0.06 | 0.11 | 0.17 | -0.31–0.58 | 0.49 |
| eIF4BP1 | 0.37 | 0.10–0.59 | 0.006 | 0.15 | -0.33–0.56 | 0.53 |
| FOXO1 | 0.25 | -0.03–0.49 | 0.07 | -0.03 | -0.48–0.43 | 0.91 |
| FOXO3 | 0.26 | -0.02–0.50 | 0.05 | -0.05 | -0.49–0.41 | 0.83 |
| MYH1 | 0.27 | -0.01–0.51 | 0.05 | -0.02 | -0.47–0.43 | 0.93 |
| MYH2 | 0.30 | 0.03–0.54 | 0.03 | 0.01 | -0.45–0.46 | 0.98 |
| MYH4 | 0.12 | -0.16–0.39 | 0.38 | -0.17 | -0.58–0.31 | 0.48 |
| Myogenin | 0.27 | -0.00–0.51 | 0.047 | 0.10 | -0.37–0.53 | 0.68 |
| SIRT1 | 0.22 | -0.07–0.46 | 0.12 | -0.35 | -0.69–0.12 | 0.12 |
| SIRT3 | 0.16 | -0.13–0.41 | 0.26 | -0.08 | -0.52–0.38 | 0.73 |
| Myostatin | 0.13 | -0.16–0.39 | 0.36 | -0.22 | -0.61–0.26 | 0.36 |
| SMAD2 | -0.13 | -0.39–0.16 | 0.36 | 0.22 | -0.26–0.61 | 0.36 |
| SMAD3 | 0.32 | 0.04–0.54 | 0.02 | -0.21 | -0.61–0.26 | 0.37 |
| SMAD4 | 0.28 | -0.00–0.51 | 0.04 | -0.10 | -0.53–0.37 | 0.67 |
| SMAD7 | -0.28 | -0.51–0.00 | 0.04 | 0.10 | -0.37–0.52 | 0.67 |
| ACVR2A | 0.27 | -0.00–0.51 | 0.046 | -0.18 | -0.58–0.29 | 0.45 |
| ACVR2B | 0.26 | -0.02–0.50 | 0.06 | -0.12 | -0.54–0.35 | 0.62 |
| RELA | 0.15 | -0.13–0.40 | 0.29 | -0.15 | -0.56–0.33 | 0.54 |
| RELB | 0.08 | -0.21–0.34 | 0.60 | 0.08 | -0.39–0.51 | 0.74 |
| IL6 | -0.26 | -0.49–0.02 | 0.06 | 0.29 | -0.18–0.66 | 0.21 |
| IL1B | -0.16 | -0.42–0.12 | 0.24 | -0.02 | -0.47–0.43 | 0.93 |
| NFKB1 | 0.17 | -0.12–0.42 | 0.23 | -0.25 | -0.63–0.23 | 0.29 |
| INSR | 0.31 | 0.03–0.54 | 0.02 | 0.11 | -0.35–0.54 | 0.61 |
| IRS1 | 0.20 | -0.08–0.45 | 0.14 | 0.02 | -0.44–0.47 | 0.94 |
| AKT1 | -0.09 | -0.35–0.19 | 0.54 | 0.07 | -0.40–0.50 | 0.77 |
| GSK3B | 0.20 | -0.08–0.46 | 0.15 | -0.19 | -0.59–0.29 | 0.43 |
| DDIT4 | 0.31 | 0.04–0.55 | 0.02 | -0.09 | -0.52–0.38 | 0.71 |
| HSD11B1 | 0.15 | -0.13–0.41 | 0.29 | -0.40 | -0.72–0.06 | 0.08 |
| HSD11B2 | -0.03 | -0.31–0.25 | 0.83 | -0.15 | -0.57–0.32 | 0.53 |
| H6PD | 0.25 | -0.03–0.49 | 0.07 | -0.14 | -0.56–0.33 | 0.55 |
| HSP90AA1 | 0.35 | 0.08–0.57 | 0.01 | 0.21 | -0.27–0.61 | 0.37 |
| HSP90B1 | 0.12 | -0.16–0.39 | 0.38 | -0.14 | -0.56–0.33 | 0.56 |
| GHR | 0.19 | -0.09–0.44 | 0.17 | -0.23 | -0.62–0.24 | 0.33 |
| GHSR | -0.12 | -0.39–0.16 | 0.39 | -0.35 | -0.69–0.12 | 0.14 |
| IGF1 | -0.11 | -0.38–0.17 | 0.42 | -0.37 | -0.70–0.10 | 0.11 |
| HIF1A | 0.16 | -0.12–0.42 | 0.24 | -0.26 | -0.64–0.21 | 0.25 |
| EIF6 | -0.01 | -0.29–0.27 | 0.94 | 0.06 | -0.40–0.50 | 0.80 |
| EIF2B1 | 0.28 | 0.00–0.52 | 0.04 | -0.22 | -0.61–0.26 | 0.35 |
| PDK4 | 0.15 | -0.13–0.41 | 0.27 | 0.31 | -0.17–0.66 | 0.19 |
| IGF1R | 0.35 | 0.08–0.58 | 0.009 | -0.14 | -0.55–0.33 | 0.55 |
| GADD45A | 0.19 | -0.10–0.44 | 0.18 | -0.34 | -0.69–0.13 | 0.15 |
| ACACA | 0.05 | -0.22–0.32 | 0.71 | -0.48 | -0.77–-0.03 | 0.03 |
| AR | 0.22 | -0.06–0.47 | 0.11 | -0.20 | -0.60–0.27 | 0.39 |
| CD36 | 0.21 | -0.07–0.46 | 0.12 | 0.12 | -0.35–0.54 | 0.60 |
| CDKN1A | -0.03 | -0.30–0.25 | 0.82 | -0.29 | -0.66–0.19 | 0.22 |
| CEBPB | 0.26 | -0.01–0.50 | 0.06 | -0.16 | -0.58–0.31 | 0.48 |
| CRYAB | 0.34 | 0.07–0.56 | 0.01 | 0.15 | -0.32–0.56 | 0.52 |
| CYCS | 0.39 | 0.13–0.60 | 0.004 | 0.29 | -0.18–0.66 | 0.21 |
| GLUL | 0.35 | 0.08–0.57 | 0.01 | 0.07 | -0.39–0.51 | 0.75 |
| HSL | 0.08 | -0.20–0.34 | 0.58 | 0.21 | -0.27–0.60 | 0.38 |
| LPL | 0.15 | -0.13–0.41 | 0.29 | -0.01 | -0.46–0.44 | 0.97 |
| MYCL1 | 0.01 | -0.26–0.28 | 0.93 | 0.01 | -0.45–0.46 | 0.97 |
| MYF5 | 0.21 | -0.07–0.46 | 0.13 | 0.21 | -0.27–0.60 | 0.38 |
| NR3C1 | -0.11 | -0.37–0.17 | 0.43 | -0.18 | -0.59–0.30 | 0.45 |
| PPARD | 0.28 | 0.00–0.52 | 0.04 | -0.17 | -0.58–0.30 | 0.46 |
| PPARG | -0.03 | -0.30–0.25 | 0.82 | -0.30 | -0.66–0.18 | 0.20 |
| PPARGC1A | 0.35 | 0.08–0.57 | 0.01 | 0.11 | -0.36–0.54 | 0.63 |
| PPP3R2 | -0.17 | -0.42–0.11 | 0.23 | -0.53 | -0.79–0.10 | 0.02 |
| PSMA2 | 0.09 | -0.19–0.36 | 0.49 | -0.45 | -0.75–0.06 | 0.04 |
| PSMC1 | 0.16 | -0.12–0.42 | 0.24 | -0.05 | -0.50–0.40 | 0.82 |
| PSMC2 | 0.24 | -0.04–0.48 | 0.08 | -0.18 | -0.58–0.30 | 0.44 |
| PSMC4 | 0.27 | 0.00–0.51 | 0.048 | -0.09 | -0.52–0.38 | 0.70 |
| PSMC5 | 0.28 | 0.00–0.51 | 0.04 | -0.05 | -0.49–0.41 | 0.83 |
| PSMC6 | 0.23 | -0.05–0.47 | 0.10 | 0.08 | -0.39–0.51 | 0.74 |
| PSMD1 | 0.21 | -0.07–0.46 | 0.12 | -0.16 | -0.57–0.32 | 0.51 |
| PSMD11 | 0.28 | 0.00–0.51 | 0.04 | -0.03 | -0.48–0.42 | 0.88 |
| PSMD12 | 0.27 | 0.00–0.51 | 0.04 | 0.01 | -0.45–0.46 | 0.97 |
| PSMD14 | 0.33 | 0.06–0.55 | 0.02 | 0.14 | -0.34–0.56 | 0.56 |
| PSMD2 | 0.18 | -0.10–0.43 | 0.20 | -0.08 | -0.52–0.38 | 0.72 |
| PSMD3 | 0.07 | -0.21–0.34 | 0.60 | -0.04 | -0.48–0.42 | 0.87 |
| PSMD4 | 0.04 | -0.23–0.31 | 0.75 | -0.37 | -0.70–0.11 | 0.11 |
| PSMD6 | 0.11 | -0.17–0.37 | 0.42 | 0.14 | -0.33–0.55 | 0.55 |
| PSMD7 | 0.21 | -0.07–0.45 | 0.13 | -0.05 | -0.49–0.41 | 0.82 |
| RPS6KB1 | 0.24 | -0.03–0.49 | 0.08 | -0.18 | -0.59–0.30 | 0.45 |
| RXRG | 0.40 | 0.14–0.61 | 0.003 | 0.25 | -0.23–0.62 | 0.30 |
| SLC2A4 | 0.19 | -0.09–0.45 | 0.16 | -0.05 | -0.49–0.41 | 0.82 |
| SOCSS3 | -0.06 | -0.33–0.22 | 0.65 | 0.10 | -0.37–0.53 | 0.67 |
| SOD1 | 0.29 | 0.02–0.53 | 0.03 | -0.12 | -0.55–0.35 | 0.60 |
| SREBF1 | 0.08 | -0.20–0.35 | 0.56 | -0.49 | -0.77–-0.05 | 0.03 |
| TGFB1 | -0.05 | -0.32–0.22 | 0.70 | -0.30 | -0.66–0.18 | 0.21 |
| TNFA | -0.09 | -0.35–0.19 | 0.53 | 0.02 | -0.43–0.47 | 0.92 |
| TRIM54 | 0.23 | -0.05–0.47 | 0.10 | 0.11 | -0.37–0.53 | 0.65 |