Fig 6. CFZ is efficacious in a mouse model of acute cryptosporidiosis.
Fecal oocyst recovery from IFN-γ-/- mice commenced three days after oral delivery of C. parvum oocysts. Line graph data are weight-adjusted mean oocyst counts ± SD (n = 4); inset bar graphs are mean % recovery relative to mock-treated control mice ± SEM (n = 4). (A) Mice were infected with 104 oocysts then treated orally with 10 mg/kg BKI-1294 (light gray) or CFZ (dark gray) on days 4, 5, and 6 p.i. Dotted line is the reliable limit of detection. A two-way ANOVA was conducted to determine significance between mice treated with compound vs mice treated with vehicle: * p < 0.05; ** p < 0.01. (B) Mice were infected with 106 oocysts then treated orally with a single dose of 100 mg/kg CFZ on day 4. Multiple Student’s t-tests were used to determine significance between vehicle-treated and CFZ-treated mice: * p < 0.05; ** p < 0.01.